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Interaction between DC-SIGN and DC-SIGNR with HHV-8 (LANA-1) and HIV-p24 in Castleman disease
Published 2019Get full text
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Sensitivity analysis approaches for incomplete longitudinal data in a multi-centre clinical trial
Published 2020“…It is recommended that when drawing statistical inferences in the presence of missing data, methods of analysis based on plausible scientific assumptions should be used. …”
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Internalizing mental disorders in HIV : the role of environment, telomere length and selected genetic variants
Published 2020Get full text
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Triazolyl Ru(II), Os(II), and Ir(III) complexes as potential HIV-1 entry inhibitors
Published 2021Get full text
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Possible effects of HIV infection on overall survival of patients diagnosed with acute myeloid leukaemia
Published 2020Get full text
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The lung microbiome of Human Immunodeficiency Virus-infected patients with active pulmonary Mycobacterium tuberculosis infection
Published 2022Get full text
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Human immunodeficiency virus (HIV) and Human papillomavirus (HPV) infection and cell cycle regulators in preinvasive lesions and invasive carcinomas of the anus
Published 2017“…The majority of these carcinomas are squamous cell carcinomas and are associated with high risk-HPV infection. HIV infection appears to interact synergistically with high risk-HPV in the development of squamous cell carcinoma at this site. …”
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Identification of evolutionarily conserved nucleic acid secondary structures within viral genomes
Published 2014“…In addition to the identification of individual structural elements, a large-scale analysis of HIV-1 and seven flavivirus species revealed statistically significant associations between base-paired nucleotide positions and various patterns of mutation. …”
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Sickle cell trait and targeted genomic variants in chronic kidney disease an African cohort
Published 2020“…Molecular methods: SCT heterozygosity was determined by RFLP-PCR using the restriction enzyme DdeI. …”
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Leveraging the microbiome in host genome wide association studies
Published 2021“…Philosophically, the non-parametric specification amounts to the addition of an infinite amount of prior information about all fine details of the parameters being modelled; thus represents an attractive strategy. The utility of the method is demonstrated through simulation experiments and application to real microbiome datasets for schizophrenia, HIV/AIDS, and atherosclerosis diseases, where it is shown that the method is not only robust but also has high statistical power for association inference, resulting in a framework that can contribute to our understanding of the link between the microbiome and human diseases. …”
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A survey of reasons for encounter and diagnoses in ambulatory primary care : Tygerberg Sub District, Cape Town Metropole
Published 2017Get full text
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Epidemiology and genetic risk factors of suicidal behaviour in South Africa
Published 2024“…. • To describe healthcare utilisation 12 months before suicidal behaviour among individuals who attempted suicide and who died by suicide, to identify opportunities for prevention in Cape Town, South Africa (Study 4). Methods: This thesis included an ecological time-series study of national suicide mortality data from Statistics South Africa using joinpoint regression analysis (Study 1, N=10.3 million recorded deaths from 1997 to 2016; 8,573 deaths from suicide); a conditional logistic regression analysis of an attempted suicide hospital-based case-control study (Study 2, N=400; 200 cases and controls); a genome-wide genetic correlation study of suicidal ideation, self-harm, attempted and fatal suicide (samples [n] ranged from 62,648 to 125,844), and selected psychiatric disorders (n ranged from 9,954 to 386,533) using a genomic structural equation modelling approach (Study 3); and a retrospective cohort of linked electronic health records of individuals who attempted suicide and were admitted to hospital and a case series of fatal suicides on whom forensic autopsies were performed at a mortuary in Cape Town (Study 4, N=484). …”
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