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Testing for host adaptive evolution using the maize streak virus model
Published 2022“…MSV is a single stranded DNA (ssDNA) virus which, like RNA viruses, has high mutation and recombination rates. …”
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A study of the strain evolution and recombination of South African isolates of Potato virus Y
Published 2012Get full text
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Experimental investigations of mastrevirus molecular biology and evolution
Published 2014Get full text
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Evolution of sensory neuropathy after initiation of antiretroviral therapy
Published 2019“…Introduction: We studied the evolution of sensory neuropathy after antiretroviral therapy (ART) in human immunodeficiency virus–infected South Africans. …”
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Disentangling the effects of the Agulhas current on marine viruses
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Characterisation of HIV superinfection : genetic evolution and adaptive immune responses
Published 2014Get full text
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HIV-1 strain-specific neutralizing antibody responses and the dynamics of viral evolution
Published 2018“…There is evidence to suggest that in some individuals who develop bnAbs, the development of breadth is influenced by the co-evolution of the transmitted/founder (t/f) virus and earlier strain-specific neutralizing antibody (ssnAb) responses. …”
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MOLECULAR AND ANTIGENIC CHARACTERISATION OF INFLUENZA VIRUSES ISOLATED FROM HORSES IN NIGERIA
Published 1995-10ThesisFull Text AvailableAccess Repository -
Modelling the potential role of control strategies on Ebola virus disease dynamics
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Molecular genetic analysis of some enzootic rabies viruses of southern Africa
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The impact of neutralizing antibody and ADCC responses on HIV-1 envelope evolution in early infection
Published 2018“…However, evidence from the RV144 vaccine trial and non-human primate vaccine studies suggest antibody-dependent cellular cytotoxicity (ADCC) responses, which target virus-infected cells, may also be protective. This thesis uses deep sequencing, together with immune assays, to characterise HIV-1 Envelope evolution associated with both nAb and ADCC responses in early infection, and investigates broadly neutralizing and non-neutralizing monoclonal antibody ADCC activity against subtype C viruses. …”
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Radiological progression of lung disease in Human Immunodeficiency Virus (HIV)-infected children
Published 2016“…Introduction: There are limited data on the chest X-ray (CXR) abnormalities in human immunodeficiency virus (HIV)-infected children in low- and middle-income countries (LMIC's). …”
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Modelling the Evolution of HIV-1 Protein-Coding Sequences with Particular focus on the early stages of Infection
Published 2014“…However, sequence samples from the earliest phase of HIV infection are scarce, and inferences about the nature of the infecting virus and its evolution during the course of early infection are often made from samples isolated from later stages, or from chronic infections. …”
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Molecular characterisation of peste des petits ruminants viruses in sheep and goats from Nigeria
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The evolutionary impacts of secondary structures within genomes of eukaryote-infecting single-stranded DNA viruses
Published 2016Get full text
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