Zero-inflated and hurdle models with an application to the number of involved axillary lymph nodes in patients with breast cancer in Zimbabwe: A bootstrap resampling validation approach

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Investigating role of IL-4 receptor alpha (IL-4Ra) in murine models of atopic dermatitis by Scibiorek, Martyna

“…We investigated the importance of interleukin 4 receptor alpha (IL- 4Rα) signalling specifically on B and T cells to understand the requirement of this signalling axis in epicutaneous skin sensitisation during AD. We investigated 3 models of AD using House dust mite (HDM), Ovalbumin (OVA) and low-calcemic analog of vitamin D (MC903) on mouse strains lacking IL-4Ra on various B and T cells. …”
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Investigating the role of sestrin 1 and sestrin 2 in preclinical models of tuberculosis disease by Naidoo, Saiyukthi

“…By generating Sesn2 and macrophage-specific Sesn1 knockout mouse models, we uncovered the role of these genes for the first time in inflammation and TB disease. …”
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The role of Cysteinyl leukotriene receptor-1 during experimental helminth infections in murine model by Mosala, Paballo Pertunia

“…In conclusion, the current study demonstrated both positive and negative roles for cysLTs signaling through cysLTR1 during different helminth infection models. Absence of cysLTR1 during N. brasiliensis leads to delayed expulsion of adult worms and impaired recall of memory responses, indicating that cysteinyl leukotriene signaling via cysLTR1 is essential for orchestrating host protective responses. …”
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Comparative immune-profiling of three cattle breeds infested with Rhipicephalus microplus and Ixodes ricinus-infested BALB/c mice

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Prolonged tuberculosis-associated immune reconstitution inflammatory syndrome: characteristics and risk factors by Bana, Tasnim Mohammed

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Characterization of tuberculous lesions in naturally infected African buffalo (Syncerus caffer) by Laisse, Claudio Joao Mourao

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The evaluation of a BCG vaccine against bovine tuberculosis in African buffaloes (Syncerus caffer)

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Investigating the role of IL-4Rα mediated signalling on Foxp3⁺ T regulatory cells during cutaneous leishmaniasis by Maine, Rebeng

“…To investigate this further, a novel BALB/c model was utilized in which the IL-4Rα chain was conditionally knocked out on Treg cells (Foxp3ᶜʳᵉIL-4Rα⁻^/ˡᵒˣ mice). …”
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The role of Interleukin-4 induced gene 1 (IL-4i1) in allergic asthma and atopic dermatitis by Ngomti, Amkele

“…In both disease models, we saw a significant reduction in total IgE in IL-4i1- deficient mice compared to IL-4i1+/+ littermate controls. …”
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Influence of helminth infection on vaginal immunity by Omondi, Fidilia

“…We then investigated the impact of primary helminth infection on B and T cell immunity in the female reproductive tract using the mouse model of hookworm infection, Nippostrongylus brasiliensis. …”
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Regulation of HPV infection and cervical cancer development following a helminth infection by Butters, Claire

“…These results were then validated in vivo, through the development of a physiological murine model for HPV infec7on, u7lising a luminescent HPV PsV and in vivo imaging system (IVIS). …”
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Comparative immune-profiling of tick vaccine formulations and the role of co-infestation with Babesia microti in Ixodes ricinus-infested BALB/c mice

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Bronchoscopic assessment and management of children presenting with clinically significant airway obstruction due to tuberculosis by Goussard, Pierre

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Feature detection in ultrasound images for computer aided diagnosis of Hodgkin's Lymphoma by Dawood, Tareen

“…A support vector machine model was built, with two experiments performed to evaluate the model. …”
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The characterisation of dendritic cell, microglial, macrophage and T cell responses during mycobacterial infection of the central nervous system by Kgoadi, Khanyisile

“…Conclusion: We successfully reproduced the CNS-TB murine model, which proved valuable in studying immune responses. …”
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Invasive carcinoma of the cervix in young women : a controlled study (1974-1983) including re-examination of the histology and cytology for evidence of human papillomavirus infecti... by Jennings, O G N

“…Multivariate analysis with a proportional hazards general linear model was performed for simultaneous control of confounding factors. …”
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Proteogenomics of the Spotted Hyena (Crocuta crocuta) by Swartz, Aidan

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Chronic stress-associated accelerated ageing: inflammation and oxidative stress treatment by Petersen-Ross, Kelly Shirley

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Investigating the molecular pathogenesis of tuberculosis-associated immune reconstitution inflammatory syndrome by Moseki, Raymond

“…Two candidate drugs (anakinra and parthenolide) were evaluated and benchmarked against the standard of care (prednisolone) in an ex vivo mycobacterial cell stimulation model using patient samples. Both anakinra and parthenolide significantly reduced several markers of inflammation compared to prednisolone. …”
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