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Investigation into the effects of the tobacco smoke procarcinogen benzo[a]pyrene on gene expression profiles in oesophageal cancer
Includes bibliographical references (p. 125-140).
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| Main Author: | |
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
| Published: |
Division of Medical Biochemistry
2014
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| _version_ | 1867614403606609920 |
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| access_status_str | Open Access |
| author | Bick, Alexis J |
| author2 | Parker, M Iqbal |
| author_browse | Bick, Alexis J Parker, M Iqbal |
| author_facet | Parker, M Iqbal Bick, Alexis J |
| author_sort | Bick, Alexis J |
| collection | Thesis |
| description | Includes bibliographical references (p. 125-140). |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/10124 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:51:29.670Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2014 |
| publishDateRange | 2014 |
| publishDateSort | 2014 |
| publisher | Division of Medical Biochemistry |
| publisherStr | Division of Medical Biochemistry |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/10124 Investigation into the effects of the tobacco smoke procarcinogen benzo[a]pyrene on gene expression profiles in oesophageal cancer Bick, Alexis J Parker, M Iqbal Medical Biochemistry Includes bibliographical references (p. 125-140). Tobacco smoking is a major risk factor in the development of oesophageal squamous cell carcinoma (OSCC). Benzo[a]pyrene (BaP) is a tobacco smoke procarcinogen that is metabolically activated into the carcinogenic benzo[a]pyrene diol-epoxide (BPDE) by the CYP1 family of cytochrome P450 enzymes. BaP is a ligand for the aryl hydrocarbon receptor (AhR) which activates CYP1 gene transcription. Polymorphisms in these genes affect enzyme activity and therefore BaP bioactivation. 2014-12-26T14:16:51Z 2014-12-26T14:16:51Z 2011 Master Thesis Masters MSc http://hdl.handle.net/11427/10124 eng application/pdf Division of Medical Biochemistry Faculty of Health Sciences University of Cape Town |
| spellingShingle | Medical Biochemistry Bick, Alexis J Investigation into the effects of the tobacco smoke procarcinogen benzo[a]pyrene on gene expression profiles in oesophageal cancer |
| thesis_degree_str | Master's |
| title | Investigation into the effects of the tobacco smoke procarcinogen benzo[a]pyrene on gene expression profiles in oesophageal cancer |
| title_full | Investigation into the effects of the tobacco smoke procarcinogen benzo[a]pyrene on gene expression profiles in oesophageal cancer |
| title_fullStr | Investigation into the effects of the tobacco smoke procarcinogen benzo[a]pyrene on gene expression profiles in oesophageal cancer |
| title_full_unstemmed | Investigation into the effects of the tobacco smoke procarcinogen benzo[a]pyrene on gene expression profiles in oesophageal cancer |
| title_short | Investigation into the effects of the tobacco smoke procarcinogen benzo[a]pyrene on gene expression profiles in oesophageal cancer |
| title_sort | investigation into the effects of the tobacco smoke procarcinogen benzo a pyrene on gene expression profiles in oesophageal cancer |
| topic | Medical Biochemistry |
| url | http://hdl.handle.net/11427/10124 |
| work_keys_str_mv | AT bickalexisj investigationintotheeffectsofthetobaccosmokeprocarcinogenbenzoapyreneongeneexpressionprofilesinoesophagealcancer |