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Studies on in vitro human T cell reactivity to antigens of mycobacterium tuberculosis
Studies on Mycobacterium tuberculosis (MTB) antigens are important to improve immunodiagnostics and vaccine efficacy. A novel genome based strategy for antigen discovery is to relate what is highly expressed by bacilli in vivo or in vitro, to what is recognized by human T cells as antigens. As hypox...
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| Format: | Thesis |
| Language: | English |
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Division of Medical Microbiology
2014
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| _version_ | 1867613300717518848 |
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| access_status_str | Open Access |
| author | Gideon, Hannah Priyadarshini |
| author2 | Wilkinson, Robert J |
| author_browse | Gideon, Hannah Priyadarshini Wilkinson, Robert J |
| author_facet | Wilkinson, Robert J Gideon, Hannah Priyadarshini |
| author_sort | Gideon, Hannah Priyadarshini |
| collection | Thesis |
| description | Studies on Mycobacterium tuberculosis (MTB) antigens are important to improve immunodiagnostics and vaccine efficacy. A novel genome based strategy for antigen discovery is to relate what is highly expressed by bacilli in vivo or in vitro, to what is recognized by human T cells as antigens. As hypoxia is a relevant stimulus that MTB encounters in vivo, whole genome based transcriptional profiles of M. tuberculosis subject to prolonged hypoxia (described as the Enduring hypoxic response (EHR) were analyzed, to guide the discovery of novel potential anitgens, by a combined bioinformatic and empirical approach and to determine evidence of infection stage specific recognition. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/10500 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:33:57.504Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2014 |
| publishDateRange | 2014 |
| publishDateSort | 2014 |
| publisher | Division of Medical Microbiology |
| publisherStr | Division of Medical Microbiology |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/10500 Studies on in vitro human T cell reactivity to antigens of mycobacterium tuberculosis Gideon, Hannah Priyadarshini Wilkinson, Robert J Wilkinson, Katalin Medical Microbiology Studies on Mycobacterium tuberculosis (MTB) antigens are important to improve immunodiagnostics and vaccine efficacy. A novel genome based strategy for antigen discovery is to relate what is highly expressed by bacilli in vivo or in vitro, to what is recognized by human T cells as antigens. As hypoxia is a relevant stimulus that MTB encounters in vivo, whole genome based transcriptional profiles of M. tuberculosis subject to prolonged hypoxia (described as the Enduring hypoxic response (EHR) were analyzed, to guide the discovery of novel potential anitgens, by a combined bioinformatic and empirical approach and to determine evidence of infection stage specific recognition. 2014-12-30T06:34:33Z 2014-12-30T06:34:33Z 2010 Doctoral Thesis Doctoral PhD http://hdl.handle.net/11427/10500 eng application/pdf Division of Medical Microbiology Faculty of Health Sciences University of Cape Town |
| spellingShingle | Medical Microbiology Gideon, Hannah Priyadarshini Studies on in vitro human T cell reactivity to antigens of mycobacterium tuberculosis |
| thesis_degree_str | Doctoral |
| title | Studies on in vitro human T cell reactivity to antigens of mycobacterium tuberculosis |
| title_full | Studies on in vitro human T cell reactivity to antigens of mycobacterium tuberculosis |
| title_fullStr | Studies on in vitro human T cell reactivity to antigens of mycobacterium tuberculosis |
| title_full_unstemmed | Studies on in vitro human T cell reactivity to antigens of mycobacterium tuberculosis |
| title_short | Studies on in vitro human T cell reactivity to antigens of mycobacterium tuberculosis |
| title_sort | studies on in vitro human t cell reactivity to antigens of mycobacterium tuberculosis |
| topic | Medical Microbiology |
| url | http://hdl.handle.net/11427/10500 |
| work_keys_str_mv | AT gideonhannahpriyadarshini studiesoninvitrohumantcellreactivitytoantigensofmycobacteriumtuberculosis |