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HIV pathogenesis in the female genital tract during chronic HIV infection : the impact of inflammation, T cell memory differentiation status and homeostatic cytokines on mucosal T cell immunity
Includes bibliographical references (leaves 124-150).
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| Main Author: | |
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
| Published: |
Division of Virology
2014
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| _version_ | 1867613253714051072 |
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| access_status_str | Open Access |
| author | Gumbi, Pamela |
| author2 | Passmore, Jo-Ann |
| author_browse | Gumbi, Pamela Passmore, Jo-Ann |
| author_facet | Passmore, Jo-Ann Gumbi, Pamela |
| author_sort | Gumbi, Pamela |
| collection | Thesis |
| description | Includes bibliographical references (leaves 124-150). |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/10501 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:33:12.104Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2014 |
| publishDateRange | 2014 |
| publishDateSort | 2014 |
| publisher | Division of Virology |
| publisherStr | Division of Virology |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/10501 HIV pathogenesis in the female genital tract during chronic HIV infection : the impact of inflammation, T cell memory differentiation status and homeostatic cytokines on mucosal T cell immunity Gumbi, Pamela Passmore, Jo-Ann Medical Virology Includes bibliographical references (leaves 124-150). The female genital tract serves as the major portal of entry for human immunodeficiency virus (HIV). Local immune factors unique to the mucosal micro-environment such as the genital tract cytokine milieu or the activation/differentiation status of T cells may play a significant role in heterosexual transmission of HIV and subsequent pathogenesis. Elucidation of the mechanisms underlying the persistent recruitment, activation and differentiation of mucosal T cells will give crucial insight into potential therapeutic targets to restore effective local immunity. 2014-12-30T06:35:01Z 2014-12-30T06:35:01Z 2010 Doctoral Thesis Doctoral PhD http://hdl.handle.net/11427/10501 eng application/pdf Division of Virology Faculty of Health Sciences University of Cape Town |
| spellingShingle | Medical Virology Gumbi, Pamela HIV pathogenesis in the female genital tract during chronic HIV infection : the impact of inflammation, T cell memory differentiation status and homeostatic cytokines on mucosal T cell immunity |
| thesis_degree_str | Doctoral |
| title | HIV pathogenesis in the female genital tract during chronic HIV infection : the impact of inflammation, T cell memory differentiation status and homeostatic cytokines on mucosal T cell immunity |
| title_full | HIV pathogenesis in the female genital tract during chronic HIV infection : the impact of inflammation, T cell memory differentiation status and homeostatic cytokines on mucosal T cell immunity |
| title_fullStr | HIV pathogenesis in the female genital tract during chronic HIV infection : the impact of inflammation, T cell memory differentiation status and homeostatic cytokines on mucosal T cell immunity |
| title_full_unstemmed | HIV pathogenesis in the female genital tract during chronic HIV infection : the impact of inflammation, T cell memory differentiation status and homeostatic cytokines on mucosal T cell immunity |
| title_short | HIV pathogenesis in the female genital tract during chronic HIV infection : the impact of inflammation, T cell memory differentiation status and homeostatic cytokines on mucosal T cell immunity |
| title_sort | hiv pathogenesis in the female genital tract during chronic hiv infection the impact of inflammation t cell memory differentiation status and homeostatic cytokines on mucosal t cell immunity |
| topic | Medical Virology |
| url | http://hdl.handle.net/11427/10501 |
| work_keys_str_mv | AT gumbipamela hivpathogenesisinthefemalegenitaltractduringchronichivinfectiontheimpactofinflammationtcellmemorydifferentiationstatusandhomeostaticcytokinesonmucosaltcellimmunity |