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Protein-protein interactions of human somatic angiotensin-converting enzyme

In this study, novel disulphide bridges were engineered into the linker region of ACE [Angiotensin-converting enzyme] in an attempt to limit inter-domain movement, thereby producing a candidate for crystallisation and to determine the effect of these bridges on inter-domain movement.

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Bibliographic Details
Main Author: Gordon, Kerry
Other Authors: Sturrock, Edward D
Format: Thesis
Language:English
Published: Division of Medical Biochemistry 2014
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Summary:In this study, novel disulphide bridges were engineered into the linker region of ACE [Angiotensin-converting enzyme] in an attempt to limit inter-domain movement, thereby producing a candidate for crystallisation and to determine the effect of these bridges on inter-domain movement.