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Computational rationale for the selective inhibition of the herpes simplex virus type 1 uracil-DNA glycosylase enzyme
In this thesis I will investigate the binding pocket and analyse the nature of binding of the 6-(4-Alkylanilino)-uracil inhibitors in hsvUDG and hUDG to provide a platform for the development of improved inhibitors.
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| Format: | Thesis |
| Language: | English |
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Department of Chemistry
2015
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| _version_ | 1867613184959971329 |
|---|---|
| access_status_str | Open Access |
| author | Hendricks, Umraan |
| author2 | Naidoo, Kevin J |
| author_browse | Hendricks, Umraan Naidoo, Kevin J |
| author_facet | Naidoo, Kevin J Hendricks, Umraan |
| author_sort | Hendricks, Umraan |
| collection | Thesis |
| description | In this thesis I will investigate the binding pocket and analyse the nature of binding of the 6-(4-Alkylanilino)-uracil inhibitors in hsvUDG and hUDG to provide a platform for the development of improved inhibitors. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/11049 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:32:07.214Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2015 |
| publishDateRange | 2015 |
| publishDateSort | 2015 |
| publisher | Department of Chemistry |
| publisherStr | Department of Chemistry |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/11049 Computational rationale for the selective inhibition of the herpes simplex virus type 1 uracil-DNA glycosylase enzyme Hendricks, Umraan Naidoo, Kevin J Chemistry In this thesis I will investigate the binding pocket and analyse the nature of binding of the 6-(4-Alkylanilino)-uracil inhibitors in hsvUDG and hUDG to provide a platform for the development of improved inhibitors. 2015-01-02T09:26:31Z 2015-01-02T09:26:31Z 2011 Master Thesis Masters MSc http://hdl.handle.net/11427/11049 eng application/pdf Department of Chemistry Faculty of Science University of Cape Town |
| spellingShingle | Chemistry Hendricks, Umraan Computational rationale for the selective inhibition of the herpes simplex virus type 1 uracil-DNA glycosylase enzyme |
| thesis_degree_str | Master's |
| title | Computational rationale for the selective inhibition of the herpes simplex virus type 1 uracil-DNA glycosylase enzyme |
| title_full | Computational rationale for the selective inhibition of the herpes simplex virus type 1 uracil-DNA glycosylase enzyme |
| title_fullStr | Computational rationale for the selective inhibition of the herpes simplex virus type 1 uracil-DNA glycosylase enzyme |
| title_full_unstemmed | Computational rationale for the selective inhibition of the herpes simplex virus type 1 uracil-DNA glycosylase enzyme |
| title_short | Computational rationale for the selective inhibition of the herpes simplex virus type 1 uracil-DNA glycosylase enzyme |
| title_sort | computational rationale for the selective inhibition of the herpes simplex virus type 1 uracil dna glycosylase enzyme |
| topic | Chemistry |
| url | http://hdl.handle.net/11427/11049 |
| work_keys_str_mv | AT hendricksumraan computationalrationalefortheselectiveinhibitionoftheherpessimplexvirustype1uracildnaglycosylaseenzyme |