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Investigating crosstalk in lipid rafts between the glucocorticoid receptor and gonadotropin-releasing hormone receptor signaling pathways in a gonadotrope cell line
Includes abstract.
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| Main Author: | |
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
| Published: |
Department of Molecular and Cell Biology
2015
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| _version_ | 1867613276816277504 |
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| access_status_str | Open Access |
| author | Wehmeyer, Lance |
| author2 | Hapgood, Janet P |
| author_browse | Hapgood, Janet P Wehmeyer, Lance |
| author_facet | Hapgood, Janet P Wehmeyer, Lance |
| author_sort | Wehmeyer, Lance |
| collection | Thesis |
| description | Includes abstract. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/11346 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:33:33.643Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2015 |
| publishDateRange | 2015 |
| publishDateSort | 2015 |
| publisher | Department of Molecular and Cell Biology |
| publisherStr | Department of Molecular and Cell Biology |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/11346 Investigating crosstalk in lipid rafts between the glucocorticoid receptor and gonadotropin-releasing hormone receptor signaling pathways in a gonadotrope cell line Wehmeyer, Lance Hapgood, Janet P Kotitschke, Andrea Cell Biology Includes abstract. Includes bibliographical references (leaves 121-158). A recent study from the Hapgood laboratory demonstrated the presence of a novel crosstalk mechanism between the glucocorticoid receptor (GR) and gonadotropin-releasing hormone receptor (GnRHR), indicating an additional direct mechanism for the effects of stress on reproduction. The present study investigated whether this crosstalk between the GR and GnRHR involves the co-localization of these receptors to lipid rafts, providing a specialized distinct region where the receptors can be in close proximity and reciprocally modulate each other’s signaling pathways. 2015-01-05T06:46:53Z 2015-01-05T06:46:53Z 2010 Master Thesis Masters MSc http://hdl.handle.net/11427/11346 eng application/pdf Department of Molecular and Cell Biology Faculty of Science University of Cape Town |
| spellingShingle | Cell Biology Wehmeyer, Lance Investigating crosstalk in lipid rafts between the glucocorticoid receptor and gonadotropin-releasing hormone receptor signaling pathways in a gonadotrope cell line |
| thesis_degree_str | Master's |
| title | Investigating crosstalk in lipid rafts between the glucocorticoid receptor and gonadotropin-releasing hormone receptor signaling pathways in a gonadotrope cell line |
| title_full | Investigating crosstalk in lipid rafts between the glucocorticoid receptor and gonadotropin-releasing hormone receptor signaling pathways in a gonadotrope cell line |
| title_fullStr | Investigating crosstalk in lipid rafts between the glucocorticoid receptor and gonadotropin-releasing hormone receptor signaling pathways in a gonadotrope cell line |
| title_full_unstemmed | Investigating crosstalk in lipid rafts between the glucocorticoid receptor and gonadotropin-releasing hormone receptor signaling pathways in a gonadotrope cell line |
| title_short | Investigating crosstalk in lipid rafts between the glucocorticoid receptor and gonadotropin-releasing hormone receptor signaling pathways in a gonadotrope cell line |
| title_sort | investigating crosstalk in lipid rafts between the glucocorticoid receptor and gonadotropin releasing hormone receptor signaling pathways in a gonadotrope cell line |
| topic | Cell Biology |
| url | http://hdl.handle.net/11427/11346 |
| work_keys_str_mv | AT wehmeyerlance investigatingcrosstalkinlipidraftsbetweentheglucocorticoidreceptorandgonadotropinreleasinghormonereceptorsignalingpathwaysinagonadotropecellline |