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Immunological characterization of the HIV-tuberculosis associated immune reconstitution inflammatory syndrome
While the integration of anti-TB and cART therapies is associated with substantial clinical improvement in the majority of patients, HIV-Tuberculosis associated Immune Reconstitution Inflammatory Syndrome (TB-IRIS) has been shown to occur in a significant subset of these patients. TB-IRIS is an infl...
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
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Institute of Infectious Disease and Molecular Medicine
2015
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| _version_ | 1867613226185785344 |
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| access_status_str | Open Access |
| author | Tadokera, Rabecca |
| author2 | Wilkinson, Robert J |
| author_browse | Tadokera, Rabecca Wilkinson, Robert J |
| author_facet | Wilkinson, Robert J Tadokera, Rabecca |
| author_sort | Tadokera, Rabecca |
| collection | Thesis |
| description | While the integration of anti-TB and cART therapies is associated with substantial clinical improvement in the majority of patients, HIV-Tuberculosis associated Immune Reconstitution Inflammatory Syndrome (TB-IRIS) has been shown to occur in a significant subset of these patients. TB-IRIS is an inflammatory complication of the combined treatments for HIV-1 and tuberculosis, which is being reported increasingly, particularly in areas endemic to both diseases. This work aimed to characterise the immunopathogenesis of paradoxical HIV-Tuberculosis associated immune reconstitution inflammatory syndrome. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/11589 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:32:46.693Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2015 |
| publishDateRange | 2015 |
| publishDateSort | 2015 |
| publisher | Institute of Infectious Disease and Molecular Medicine |
| publisherStr | Institute of Infectious Disease and Molecular Medicine |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/11589 Immunological characterization of the HIV-tuberculosis associated immune reconstitution inflammatory syndrome Tadokera, Rabecca Wilkinson, Robert J Wilkinson, Katalin Infectious Diseases While the integration of anti-TB and cART therapies is associated with substantial clinical improvement in the majority of patients, HIV-Tuberculosis associated Immune Reconstitution Inflammatory Syndrome (TB-IRIS) has been shown to occur in a significant subset of these patients. TB-IRIS is an inflammatory complication of the combined treatments for HIV-1 and tuberculosis, which is being reported increasingly, particularly in areas endemic to both diseases. This work aimed to characterise the immunopathogenesis of paradoxical HIV-Tuberculosis associated immune reconstitution inflammatory syndrome. 2015-01-06T18:45:03Z 2015-01-06T18:45:03Z 2011 Doctoral Thesis Doctoral PhD http://hdl.handle.net/11427/11589 eng application/pdf Institute of Infectious Disease and Molecular Medicine Faculty of Health Sciences University of Cape Town |
| spellingShingle | Infectious Diseases Tadokera, Rabecca Immunological characterization of the HIV-tuberculosis associated immune reconstitution inflammatory syndrome |
| thesis_degree_str | Doctoral |
| title | Immunological characterization of the HIV-tuberculosis associated immune reconstitution inflammatory syndrome |
| title_full | Immunological characterization of the HIV-tuberculosis associated immune reconstitution inflammatory syndrome |
| title_fullStr | Immunological characterization of the HIV-tuberculosis associated immune reconstitution inflammatory syndrome |
| title_full_unstemmed | Immunological characterization of the HIV-tuberculosis associated immune reconstitution inflammatory syndrome |
| title_short | Immunological characterization of the HIV-tuberculosis associated immune reconstitution inflammatory syndrome |
| title_sort | immunological characterization of the hiv tuberculosis associated immune reconstitution inflammatory syndrome |
| topic | Infectious Diseases |
| url | http://hdl.handle.net/11427/11589 |
| work_keys_str_mv | AT tadokerarabecca immunologicalcharacterizationofthehivtuberculosisassociatedimmunereconstitutioninflammatorysyndrome |