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Computational modelling of cardiac function and myocardial infarction
Includes abstract.
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| Main Author: | |
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
| Published: |
Department of Mathematics and Applied Mathematics
2015
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| _version_ | 1867613309974347776 |
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| access_status_str | Open Access |
| author | MBewu, James |
| author2 | Reddy, B Daya |
| author_browse | MBewu, James Reddy, B Daya |
| author_facet | Reddy, B Daya MBewu, James |
| author_sort | MBewu, James |
| collection | Thesis |
| description | Includes abstract. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/11611 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:34:06.076Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2015 |
| publishDateRange | 2015 |
| publishDateSort | 2015 |
| publisher | Department of Mathematics and Applied Mathematics |
| publisherStr | Department of Mathematics and Applied Mathematics |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/11611 Computational modelling of cardiac function and myocardial infarction MBewu, James Reddy, B Daya Skatulla, Sebastian Mathematics and Applied Mathematics Includes abstract. Includes bibliographical references. Cardiovascular disease is a leading cause of death in South Africa. In particular non-fatal myocardial infarction is a key determinant for future cardiac failure due to adverse remodelling and electrophysiological dysfunction. Computational modelling of the electrophysiology and mechanics of the heart can provide useful insights into the causes of cardiac failure and the efficacy of treatments designed to combat myocardial infarction. A computational model of the healthy and infarcted left ventricle of a rat was developed using the eikonal diffusion equation to simulate the electrophysiology; a continuum mechanical model incorporating a passive mechanical model of Usyk to describe the nonlinear, anisotropic and nearly compressible nature of cardiac tissue; and an active stress model of Guccione to model the contraction of cardiac tissue. Boundary conditions modelling the blood pressure on the heart wall were applied to simulate the cardiac cycle. 2015-01-06T18:51:10Z 2015-01-06T18:51:10Z 2012 Master Thesis Masters MSc http://hdl.handle.net/11427/11611 eng application/pdf Department of Mathematics and Applied Mathematics Faculty of Science University of Cape Town |
| spellingShingle | Mathematics and Applied Mathematics MBewu, James Computational modelling of cardiac function and myocardial infarction |
| thesis_degree_str | Master's |
| title | Computational modelling of cardiac function and myocardial infarction |
| title_full | Computational modelling of cardiac function and myocardial infarction |
| title_fullStr | Computational modelling of cardiac function and myocardial infarction |
| title_full_unstemmed | Computational modelling of cardiac function and myocardial infarction |
| title_short | Computational modelling of cardiac function and myocardial infarction |
| title_sort | computational modelling of cardiac function and myocardial infarction |
| topic | Mathematics and Applied Mathematics |
| url | http://hdl.handle.net/11427/11611 |
| work_keys_str_mv | AT mbewujames computationalmodellingofcardiacfunctionandmyocardialinfarction |