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Extensively drug resistant tuberculosis in South Africa
Includes abstract.
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| Main Author: | |
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
| Published: |
Department of Medicine
2015
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| _version_ | 1867613191143424000 |
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| access_status_str | Open Access |
| author | Shean, Karen Penelope |
| author2 | Dheda, Keertan |
| author_browse | Dheda, Keertan Shean, Karen Penelope |
| author_facet | Dheda, Keertan Shean, Karen Penelope |
| author_sort | Shean, Karen Penelope |
| collection | Thesis |
| description | Includes abstract. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/11620 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:32:13.078Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2015 |
| publishDateRange | 2015 |
| publishDateSort | 2015 |
| publisher | Department of Medicine |
| publisherStr | Department of Medicine |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/11620 Extensively drug resistant tuberculosis in South Africa Shean, Karen Penelope Dheda, Keertan Medicine Includes abstract. Includes bibliographical references (leaves 161-168). There are few data for treatment-related outcomes in patients with XDR tuberculosis in settings with high HIV prevalence. We reviewed the case records of 227 consecutively diagnosed South African patients with XDR-TB between 2002 and 2008, and analysed the records of another 115 patients, retrospectively, for adverse drug reactions (ADRs). It was found that a significant proportion of XDR-TB patients are HIV unrelated, and prognosis, regardless of HIV status, poor. Nevertheless, survival in HIV infected patients is better than previously reported, and treatment with HAART improves outcomes. The frequency of ADR’s with XDR-TB treatment regimens is high, often severe, and negatively impacts on culture conversion outcomes. These data have implications for the formulation of recommendations for control programmes in resource-poor settings. 2015-01-06T18:54:54Z 2015-01-06T18:54:54Z 2011 Master Thesis Masters MSc http://hdl.handle.net/11427/11620 eng application/pdf Department of Medicine Faculty of Health Sciences University of Cape Town |
| spellingShingle | Medicine Shean, Karen Penelope Extensively drug resistant tuberculosis in South Africa |
| thesis_degree_str | Master's |
| title | Extensively drug resistant tuberculosis in South Africa |
| title_full | Extensively drug resistant tuberculosis in South Africa |
| title_fullStr | Extensively drug resistant tuberculosis in South Africa |
| title_full_unstemmed | Extensively drug resistant tuberculosis in South Africa |
| title_short | Extensively drug resistant tuberculosis in South Africa |
| title_sort | extensively drug resistant tuberculosis in south africa |
| topic | Medicine |
| url | http://hdl.handle.net/11427/11620 |
| work_keys_str_mv | AT sheankarenpenelope extensivelydrugresistanttuberculosisinsouthafrica |