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Metal complexes of penicillin and cephalosporin antibiotics
Includes bibliographical references.
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| Main Author: | |
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
| Published: |
Department of Chemistry
2015
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| _version_ | 1867613196960923649 |
|---|---|
| access_status_str | Open Access |
| author | Jackson, Graham Ellis |
| author2 | Nassimbeni, Luigi R |
| author_browse | Jackson, Graham Ellis Nassimbeni, Luigi R |
| author_facet | Nassimbeni, Luigi R Jackson, Graham Ellis |
| author_sort | Jackson, Graham Ellis |
| collection | Thesis |
| description | Includes bibliographical references. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/12471 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:32:18.917Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2015 |
| publishDateRange | 2015 |
| publishDateSort | 2015 |
| publisher | Department of Chemistry |
| publisherStr | Department of Chemistry |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/12471 Metal complexes of penicillin and cephalosporin antibiotics Jackson, Graham Ellis Nassimbeni, Luigi R Linder, P W Fazakerley, G V Chemistry Includes bibliographical references. The interaction between metal-ions and the penicillin and cephalosporin antibiotics have been studied in an attempt to determine both the site and mechanism of this interaction. The solution conformation of the Cu(II) and Mn(II) complexes were determined using an n.m.r, line broadening, technique. The ligands benzylpenicillin, 6-aminopenicillanic acid, cephalothin, cephalexin, ampicillin and thiaproline were used to study the effect of structural changes in the ligand on the structure of the complex. The stability constants of several metal-ions/penicillin complexes were determined potentiometrically. These were correlated with stability constants determined for several related complexes. Finally the kinetics of the Ni(II) substitution reaction with benzylpenicillin, penicilloic acid, ampicillin and thiaproline was studied. 2015-02-11T14:20:00Z 2015-02-11T14:20:00Z 1975 Doctoral Thesis Doctoral PhD http://hdl.handle.net/11427/12471 eng application/pdf Department of Chemistry Faculty of Science University of Cape Town |
| spellingShingle | Chemistry Jackson, Graham Ellis Metal complexes of penicillin and cephalosporin antibiotics |
| thesis_degree_str | Doctoral |
| title | Metal complexes of penicillin and cephalosporin antibiotics |
| title_full | Metal complexes of penicillin and cephalosporin antibiotics |
| title_fullStr | Metal complexes of penicillin and cephalosporin antibiotics |
| title_full_unstemmed | Metal complexes of penicillin and cephalosporin antibiotics |
| title_short | Metal complexes of penicillin and cephalosporin antibiotics |
| title_sort | metal complexes of penicillin and cephalosporin antibiotics |
| topic | Chemistry |
| url | http://hdl.handle.net/11427/12471 |
| work_keys_str_mv | AT jacksongrahamellis metalcomplexesofpenicillinandcephalosporinantibiotics |