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The evolution and effectiveness of the South African antiretroviral therapy program
Includes bibliographical references
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| Main Author: | |
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
| Published: |
Department of Public Health and Family Medicine
2015
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| _version_ | 1867614404470636544 |
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| access_status_str | Open Access |
| author | Cornell, Morna Brigit |
| author2 | Myer, Landon |
| author_browse | Cornell, Morna Brigit Myer, Landon |
| author_facet | Myer, Landon Cornell, Morna Brigit |
| author_sort | Cornell, Morna Brigit |
| collection | Thesis |
| description | Includes bibliographical references |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/12759 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:51:30.494Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2015 |
| publishDateRange | 2015 |
| publishDateSort | 2015 |
| publisher | Department of Public Health and Family Medicine |
| publisherStr | Department of Public Health and Family Medicine |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/12759 The evolution and effectiveness of the South African antiretroviral therapy program Cornell, Morna Brigit Myer, Landon Public Health Includes bibliographical references Although South Africa has the largest antiretroviral therapy (ART) program worldwide, data on key outcomes like mortality and loss to follow-up (LTF) are limited. A few cohorts have published patient outcomes but there is no national reporting on ART scale-up and its impact on the health of HIV-infected individuals. Yet such monitoring of outcomes is vital to inform and improve service delivery. The International epidemiologic Databases to Evaluate AIDS Southern Africa collaboration (IeDEA-SA) was established in 2005 to collect and analyze individual level data from the larger cohorts of individuals on ART in Southern Africa. Using routine, anonymized data from the South African sites, this thesis aims to describe how the program has evolved over 10 years and to assess its effectiveness .Five quantitative analyses were performed using descriptive statistics and survival analysis methods. The studies used patient-level data on adult patients starting ART to describe characteristics and to explore outcomes and temporal changes in outcomes over time. Patient numbers ranged from 19,481 (limited to cohorts with civil identification numbers) to 83,576 adults, followed for up to 214,400 person years. The results are presented as four published papers and one submitted for publication. The thesis describes a rapid, massive scale-up of services. Despite improvements in baseline immunologic status, late diagnosis and ART initiation especially in men area challenge. 2015-05-06T14:21:40Z 2015-05-06T14:21:40Z 2014 Doctoral Thesis Doctoral PhD http://hdl.handle.net/11427/12759 eng application/pdf Department of Public Health and Family Medicine Faculty of Health Sciences University of Cape Town |
| spellingShingle | Public Health Cornell, Morna Brigit The evolution and effectiveness of the South African antiretroviral therapy program |
| thesis_degree_str | Doctoral |
| title | The evolution and effectiveness of the South African antiretroviral therapy program |
| title_full | The evolution and effectiveness of the South African antiretroviral therapy program |
| title_fullStr | The evolution and effectiveness of the South African antiretroviral therapy program |
| title_full_unstemmed | The evolution and effectiveness of the South African antiretroviral therapy program |
| title_short | The evolution and effectiveness of the South African antiretroviral therapy program |
| title_sort | evolution and effectiveness of the south african antiretroviral therapy program |
| topic | Public Health |
| url | http://hdl.handle.net/11427/12759 |
| work_keys_str_mv | AT cornellmornabrigit theevolutionandeffectivenessofthesouthafricanantiretroviraltherapyprogram AT cornellmornabrigit evolutionandeffectivenessofthesouthafricanantiretroviraltherapyprogram |