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The role of viral sequences in genetic aberrations and malignant transformation
Includes bibliographical references.
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| Main Author: | |
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
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Department of Clinical Laboratory Sciences
2015
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| _version_ | 1867613245816176640 |
|---|---|
| access_status_str | Open Access |
| author | Mwapagha, Lamech Malagho |
| author2 | Parker, Iqbal |
| author_browse | Mwapagha, Lamech Malagho Parker, Iqbal |
| author_facet | Parker, Iqbal Mwapagha, Lamech Malagho |
| author_sort | Mwapagha, Lamech Malagho |
| collection | Thesis |
| description | Includes bibliographical references. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/12870 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:33:05.164Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2015 |
| publishDateRange | 2015 |
| publishDateSort | 2015 |
| publisher | Department of Clinical Laboratory Sciences |
| publisherStr | Department of Clinical Laboratory Sciences |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/12870 The role of viral sequences in genetic aberrations and malignant transformation Mwapagha, Lamech Malagho Parker, Iqbal Medical Biochemistry Includes bibliographical references. Cancer is a leading cause of death worldwide and viral infections such as HBV/HCV and HPV have been known to be responsible for up to 20% of cancers in low- and middle-income countries. Approximately 500,000 of these deaths are due to oesophageal squamous cell carcinoma (OSSC) alone, one of the major cancers in Eastern and Southern Africa, Latin America and Asia. Previous studies have shown HPV DNA to be integrated in nearly 40% of oesophageal tumours whereas it was present in only 3% of normal healthy asymptomatic individuals, implicating it as a possible risk factor. The aim of this study was to compare the roles and effects of the E6 gene from the low risk HPV11 and high risk HPV18 on the cellular gene expression profile in order to identify genes required for the initiation of cellular transformation and also to identify genomic alterations associated with oesophageal squamous cell carcinoma. Cancer is a leading cause of death worldwide and viral infections such as HBV/HCV and HPV have been known to be responsible for up to 20% of cancers in low- and middle-income countries. Approximately 500,000 of these deaths are due to oesophageal squamous cell carcinoma (OSSC) alone, one of the major cancers in Eastern and Southern Africa, Latin America and Asia. Previous studies have shown HPV DNA to be integrated in nearly 40% of oesophageal tumours whereas it was present in only 3% of normal healthy asymptomatic individuals, implicating it as a possible risk factor. The aim of this study was to compare the roles and effects of the E6 gene from the low risk HPV11 and high risk HPV18 on the cellular gene expression profile in order to identify genes required for the initiation of cellular transformation and also to identify genomic alterations associated with oesophageal squamous cell carcinoma. 2015-05-26T14:14:50Z 2015-05-26T14:14:50Z 2014 Doctoral Thesis Doctoral PhD http://hdl.handle.net/11427/12870 eng application/pdf Department of Clinical Laboratory Sciences Faculty of Health Sciences University of Cape Town |
| spellingShingle | Medical Biochemistry Mwapagha, Lamech Malagho The role of viral sequences in genetic aberrations and malignant transformation |
| thesis_degree_str | Doctoral |
| title | The role of viral sequences in genetic aberrations and malignant transformation |
| title_full | The role of viral sequences in genetic aberrations and malignant transformation |
| title_fullStr | The role of viral sequences in genetic aberrations and malignant transformation |
| title_full_unstemmed | The role of viral sequences in genetic aberrations and malignant transformation |
| title_short | The role of viral sequences in genetic aberrations and malignant transformation |
| title_sort | role of viral sequences in genetic aberrations and malignant transformation |
| topic | Medical Biochemistry |
| url | http://hdl.handle.net/11427/12870 |
| work_keys_str_mv | AT mwapaghalamechmalagho theroleofviralsequencesingeneticaberrationsandmalignanttransformation AT mwapaghalamechmalagho roleofviralsequencesingeneticaberrationsandmalignanttransformation |