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Vitamin C status, oxidative stress, hyperglycaemia and endothelial function in critically ill patients with septic shock : an observational study
Includes bibliographical references.
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| Main Author: | |
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
| Published: |
Department of Human Biology
2015
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| _version_ | 1867613148953968640 |
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| access_status_str | Open Access |
| author | Katundu, Kondwani |
| author2 | Hill, Lauren |
| author_browse | Hill, Lauren Katundu, Kondwani |
| author_facet | Hill, Lauren Katundu, Kondwani |
| author_sort | Katundu, Kondwani |
| collection | Thesis |
| description | Includes bibliographical references. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/13286 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:31:31.816Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2015 |
| publishDateRange | 2015 |
| publishDateSort | 2015 |
| publisher | Department of Human Biology |
| publisherStr | Department of Human Biology |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/13286 Vitamin C status, oxidative stress, hyperglycaemia and endothelial function in critically ill patients with septic shock : an observational study Katundu, Kondwani Hill, Lauren Davids, Lester Nutrition Includes bibliographical references. Septic shock is associated with oxidative stress, reduced levels of plasma vitamin C and stress hyperglycaemia – all factors that may influence endothelial, and therefore, organ function. Vitamin C is an important antioxidant in human plasma; and it has been implicated in maintaining normal endothelial function during oxidative stress. The vitamin C status of critically ill patients in South African ICUs has not been well investigated; neither has the relationship between vitamin C status, oxidative stress, hyperglycaemia and endothelial function been studied in this patient group. In a prospective, cross-sectional study investigating these factors in critically ill patients with septic shock on inotropic support, serial blood samples from 25 patients were taken at days zero and one, following inotrope initiation, and on day seven after inotrope cessation. These samples were analysed for plasma vitamin C, thiobarbituric acid-reactive substances (TBARS) - as a biomarker of oxidative stress - and soluble vascular cell adhesion molecule-1 (sVCAM-1), and E-selectin, as markers of endothelial dysfunction. The plasma glucose to vitamin C ratios were also calculated. Daily clinical measures in the patients included Sequential Organ Failure Assessment (SOFA) score, mean arterial blood pressure, blood glucose, fluid balance and inotropic support. The clinical outcomes were recorded. 2015-07-02T08:37:25Z 2015-07-02T08:37:25Z 2014 Master Thesis Masters MSc (Med) http://hdl.handle.net/11427/13286 eng application/pdf Department of Human Biology Faculty of Health Sciences University of Cape Town |
| spellingShingle | Nutrition Katundu, Kondwani Vitamin C status, oxidative stress, hyperglycaemia and endothelial function in critically ill patients with septic shock : an observational study |
| thesis_degree_str | Master's |
| title | Vitamin C status, oxidative stress, hyperglycaemia and endothelial function in critically ill patients with septic shock : an observational study |
| title_full | Vitamin C status, oxidative stress, hyperglycaemia and endothelial function in critically ill patients with septic shock : an observational study |
| title_fullStr | Vitamin C status, oxidative stress, hyperglycaemia and endothelial function in critically ill patients with septic shock : an observational study |
| title_full_unstemmed | Vitamin C status, oxidative stress, hyperglycaemia and endothelial function in critically ill patients with septic shock : an observational study |
| title_short | Vitamin C status, oxidative stress, hyperglycaemia and endothelial function in critically ill patients with septic shock : an observational study |
| title_sort | vitamin c status oxidative stress hyperglycaemia and endothelial function in critically ill patients with septic shock an observational study |
| topic | Nutrition |
| url | http://hdl.handle.net/11427/13286 |
| work_keys_str_mv | AT katundukondwani vitamincstatusoxidativestresshyperglycaemiaandendothelialfunctionincriticallyillpatientswithsepticshockanobservationalstudy |