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The investiation into the synthesis of 2,5-Diphenyloxazole in Streptomyces polyantibioticus SPR
Includes bibliographical references.
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| Main Author: | |
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
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Department of Molecular and Cell Biology
2015
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| _version_ | 1867613315207790592 |
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| access_status_str | Open Access |
| author | Stegmann, Darren Edward |
| author2 | Meyers, Paul |
| author_browse | Meyers, Paul Stegmann, Darren Edward |
| author_facet | Meyers, Paul Stegmann, Darren Edward |
| author_sort | Stegmann, Darren Edward |
| collection | Thesis |
| description | Includes bibliographical references. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/13421 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:34:10.861Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2015 |
| publishDateRange | 2015 |
| publishDateSort | 2015 |
| publisher | Department of Molecular and Cell Biology |
| publisherStr | Department of Molecular and Cell Biology |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/13421 The investiation into the synthesis of 2,5-Diphenyloxazole in Streptomyces polyantibioticus SPR Stegmann, Darren Edward Meyers, Paul Molecular and Cell Biology Includes bibliographical references. As part of an antibiotic-screening programme, an actinomycete, Streptomyces polyantibioticus SPRT, was isolated from soil collected from the banks of the Umgeni River, KwaZulu-Natal Province, South Africa. It exhibited antibiosis against M. tuberculosis H37RvT, prompting interest in its antibiotic production. An antibiotic produced by S. polyantibioticus SPRT was isolated and its structure determined by nuclear magnetic resonance (NMR) and X-ray crystallography to be 2,5- diphenyloxazole (DPO). Of great interest is the independent confirmation of the antibiotic activity of DPO and extension of the data to show activity against non-replicating persistent cells of M. tuberculosis. It seems likely that 2,5-DPO is synthesized non-ribosomally by S. polyantibioticus SPRT. It is proposed that DPO is synthesised from the starting units of benzoic acid and -hydroxyphenylalanine or phenylalanine, undergoing peptide bond formation followed by cyclization and decarboxylation to form DPO. 2015-07-14T08:42:37Z 2015-07-14T08:42:37Z 2011 Master Thesis Masters MSc http://hdl.handle.net/11427/13421 eng application/pdf Department of Molecular and Cell Biology Faculty of Science University of Cape Town |
| spellingShingle | Molecular and Cell Biology Stegmann, Darren Edward The investiation into the synthesis of 2,5-Diphenyloxazole in Streptomyces polyantibioticus SPR |
| thesis_degree_str | Master's |
| title | The investiation into the synthesis of 2,5-Diphenyloxazole in Streptomyces polyantibioticus SPR |
| title_full | The investiation into the synthesis of 2,5-Diphenyloxazole in Streptomyces polyantibioticus SPR |
| title_fullStr | The investiation into the synthesis of 2,5-Diphenyloxazole in Streptomyces polyantibioticus SPR |
| title_full_unstemmed | The investiation into the synthesis of 2,5-Diphenyloxazole in Streptomyces polyantibioticus SPR |
| title_short | The investiation into the synthesis of 2,5-Diphenyloxazole in Streptomyces polyantibioticus SPR |
| title_sort | investiation into the synthesis of 2 5 diphenyloxazole in streptomyces polyantibioticus spr |
| topic | Molecular and Cell Biology |
| url | http://hdl.handle.net/11427/13421 |
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