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Synthesis, antimalarial evaluation, Ç-hematin inhibition, and in silico and in vitro ADMET profiling of 4-aminoquinoline-hydroxypyridinone hybrids
Includes abstract.
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| Main Author: | |
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
| Published: |
Department of Chemistry
2015
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| _version_ | 1867613162543513600 |
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| access_status_str | Open Access |
| author | Andayi, Warren Andrew |
| author2 | Chibale, Kelly |
| author_browse | Andayi, Warren Andrew Chibale, Kelly |
| author_facet | Chibale, Kelly Andayi, Warren Andrew |
| author_sort | Andayi, Warren Andrew |
| collection | Thesis |
| description | Includes abstract. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/14824 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:31:45.395Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2015 |
| publishDateRange | 2015 |
| publishDateSort | 2015 |
| publisher | Department of Chemistry |
| publisherStr | Department of Chemistry |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/14824 Synthesis, antimalarial evaluation, Ç-hematin inhibition, and in silico and in vitro ADMET profiling of 4-aminoquinoline-hydroxypyridinone hybrids Andayi, Warren Andrew Chibale, Kelly Egan, Timothy J Chemistry Includes abstract. With the aim of designing appropriate hybrid molecules as a strategy to fight drug resistant malaria parasites, 4-aminoquinoline-3,4-hydroxypyridinone hybrids were designed and synthesized. Their hypothesized mode of action was studied with respect to inhibition of hemozoin formation. 2015-11-10T14:22:35Z 2015-11-10T14:22:35Z 2011 Doctoral Thesis Doctoral PhD http://hdl.handle.net/11427/14824 eng application/pdf Department of Chemistry Faculty of Science University of Cape Town |
| spellingShingle | Chemistry Andayi, Warren Andrew Synthesis, antimalarial evaluation, Ç-hematin inhibition, and in silico and in vitro ADMET profiling of 4-aminoquinoline-hydroxypyridinone hybrids |
| thesis_degree_str | Doctoral |
| title | Synthesis, antimalarial evaluation, Ç-hematin inhibition, and in silico and in vitro ADMET profiling of 4-aminoquinoline-hydroxypyridinone hybrids |
| title_full | Synthesis, antimalarial evaluation, Ç-hematin inhibition, and in silico and in vitro ADMET profiling of 4-aminoquinoline-hydroxypyridinone hybrids |
| title_fullStr | Synthesis, antimalarial evaluation, Ç-hematin inhibition, and in silico and in vitro ADMET profiling of 4-aminoquinoline-hydroxypyridinone hybrids |
| title_full_unstemmed | Synthesis, antimalarial evaluation, Ç-hematin inhibition, and in silico and in vitro ADMET profiling of 4-aminoquinoline-hydroxypyridinone hybrids |
| title_short | Synthesis, antimalarial evaluation, Ç-hematin inhibition, and in silico and in vitro ADMET profiling of 4-aminoquinoline-hydroxypyridinone hybrids |
| title_sort | synthesis antimalarial evaluation c hematin inhibition and in silico and in vitro admet profiling of 4 aminoquinoline hydroxypyridinone hybrids |
| topic | Chemistry |
| url | http://hdl.handle.net/11427/14824 |
| work_keys_str_mv | AT andayiwarrenandrew synthesisantimalarialevaluationchematininhibitionandinsilicoandinvitroadmetprofilingof4aminoquinolinehydroxypyridinonehybrids |