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Protective immunity against Nippostrongylus brasiliensis requires antigen presentation by IL-4Rα responsive B cells
Includes bibliographical references.
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| Main Author: | |
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
| Published: |
Division of Immunology
2015
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| _version_ | 1867613825578041344 |
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| access_status_str | Open Access |
| author | Darby, Matthew G |
| author2 | Brombacher, Frank |
| author_browse | Brombacher, Frank Darby, Matthew G |
| author_facet | Brombacher, Frank Darby, Matthew G |
| author_sort | Darby, Matthew G |
| collection | Thesis |
| description | Includes bibliographical references. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/14954 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:42:18.418Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2015 |
| publishDateRange | 2015 |
| publishDateSort | 2015 |
| publisher | Division of Immunology |
| publisherStr | Division of Immunology |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/14954 Protective immunity against Nippostrongylus brasiliensis requires antigen presentation by IL-4Rα responsive B cells Darby, Matthew G Brombacher, Frank Horsnell, William ImmunoIogy Includes bibliographical references. Nippostrongylus brasiliensis is a parasitic nematode infection that affects rodents. B-cells have been shown to play an important role in immunity to many different infections by antibody production and T-cell activation. But B-cell function in the protective TH2 response against N. brasiliensis infection is an area of immunity that is currently not well defined. Recently, it has been shown that B-cells are essential to the resolution of a Heligomosomoides polygyrus infection, another parasitic helminth. Our aim in this study was to investigate any role that B-cells may play in response to a secondary N. brasiliensis infection by analysing the differences in immunity of wild-type and B-cell-specific IL-4Rα knockout mice after a N. brasiliensis re-infection. 2015-11-13T13:03:06Z 2015-11-13T13:03:06Z 2012 Master Thesis Masters MSc http://hdl.handle.net/11427/14954 eng application/pdf Division of Immunology Faculty of Health Sciences University of Cape Town |
| spellingShingle | ImmunoIogy Darby, Matthew G Protective immunity against Nippostrongylus brasiliensis requires antigen presentation by IL-4Rα responsive B cells |
| thesis_degree_str | Master's |
| title | Protective immunity against Nippostrongylus brasiliensis requires antigen presentation by IL-4Rα responsive B cells |
| title_full | Protective immunity against Nippostrongylus brasiliensis requires antigen presentation by IL-4Rα responsive B cells |
| title_fullStr | Protective immunity against Nippostrongylus brasiliensis requires antigen presentation by IL-4Rα responsive B cells |
| title_full_unstemmed | Protective immunity against Nippostrongylus brasiliensis requires antigen presentation by IL-4Rα responsive B cells |
| title_short | Protective immunity against Nippostrongylus brasiliensis requires antigen presentation by IL-4Rα responsive B cells |
| title_sort | protective immunity against nippostrongylus brasiliensis requires antigen presentation by il 4rα responsive b cells |
| topic | ImmunoIogy |
| url | http://hdl.handle.net/11427/14954 |
| work_keys_str_mv | AT darbymatthewg protectiveimmunityagainstnippostrongylusbrasiliensisrequiresantigenpresentationbyil4raresponsivebcells |