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Heparanoid hydrogels for cardiovascular tissue regeneration
Includes bibliographical references
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| Main Author: | |
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
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Division of Biomedical Engineering
2016
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| _version_ | 1867613219026108416 |
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| access_status_str | Open Access |
| author | Janse van Rensburg, Aliza |
| author2 | Bezuidenhout, Deon |
| author_browse | Bezuidenhout, Deon Janse van Rensburg, Aliza |
| author_facet | Bezuidenhout, Deon Janse van Rensburg, Aliza |
| author_sort | Janse van Rensburg, Aliza |
| collection | Thesis |
| description | Includes bibliographical references |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/16695 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:32:39.476Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2016 |
| publishDateRange | 2016 |
| publishDateSort | 2016 |
| publisher | Division of Biomedical Engineering |
| publisherStr | Division of Biomedical Engineering |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/16695 Heparanoid hydrogels for cardiovascular tissue regeneration Janse van Rensburg, Aliza Bezuidenhout, Deon Davies, Neil Biomedical Engineering Includes bibliographical references Heparin (Hep) and heparan sulfate (HS) have been shown to possess anticoagulative properties, inhibit smooth muscle cell proliferation, moderate inflammation and control angiogenesis by stabilization and potentiation of growth factors (GF). These properties are potentially very useful for the treatment of cardiovascular diseases, especially when delivered as injectable hydrogels that can form in situ. This project focused on developing Hep and HS hydrogels for localized GF delivery. Hep and HS were acrylated, characterized and crosslinked with PEG tetra-thiols, either directly (10m% Hep/HS-Ac, Type 1) or by copolymerization with 20PEG8Ac or 20PEG8VS (4m% copolymer; 1.5% Hep/HS-Ac) to form degradable (Type 2D) or non-degradable (Type 2N) gels, respectively. Gelation times, viscoelasticity, swelling, mesh size, Hep/HS elution and activity, as well as GF incorporation and release were studied in vitro. Type 2D gels with covalently incorporated (CI) Hep and GFs were evaluated in vivo as ingrowth matrices in porous polyurethane (PU) scaffolds for healing response in a rat subcutaneous model. 2016-02-02T14:42:02Z 2016-02-02T14:42:02Z 2015 Master Thesis Masters MSc (Med) http://hdl.handle.net/11427/16695 eng application/pdf Division of Biomedical Engineering Faculty of Health Sciences University of Cape Town |
| spellingShingle | Biomedical Engineering Janse van Rensburg, Aliza Heparanoid hydrogels for cardiovascular tissue regeneration |
| thesis_degree_str | Master's |
| title | Heparanoid hydrogels for cardiovascular tissue regeneration |
| title_full | Heparanoid hydrogels for cardiovascular tissue regeneration |
| title_fullStr | Heparanoid hydrogels for cardiovascular tissue regeneration |
| title_full_unstemmed | Heparanoid hydrogels for cardiovascular tissue regeneration |
| title_short | Heparanoid hydrogels for cardiovascular tissue regeneration |
| title_sort | heparanoid hydrogels for cardiovascular tissue regeneration |
| topic | Biomedical Engineering |
| url | http://hdl.handle.net/11427/16695 |
| work_keys_str_mv | AT jansevanrensburgaliza heparanoidhydrogelsforcardiovasculartissueregeneration |