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Development of an antirheumatic drug
Includes bibliographical references.
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| Main Author: | |
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
| Published: |
Department of Chemistry
2016
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| _version_ | 1867613164244303872 |
|---|---|
| access_status_str | Open Access |
| author | Voyi, Kuku Vinolia Vuyelwa |
| author2 | Jackson, Graham Ellis |
| author_browse | Jackson, Graham Ellis Voyi, Kuku Vinolia Vuyelwa |
| author_facet | Jackson, Graham Ellis Voyi, Kuku Vinolia Vuyelwa |
| author_sort | Voyi, Kuku Vinolia Vuyelwa |
| collection | Thesis |
| description | Includes bibliographical references. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/17187 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:31:47.142Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2016 |
| publishDateRange | 2016 |
| publishDateSort | 2016 |
| publisher | Department of Chemistry |
| publisherStr | Department of Chemistry |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/17187 Development of an antirheumatic drug Voyi, Kuku Vinolia Vuyelwa Jackson, Graham Ellis Antirheumatic Agents Rheumatism - Chemotherapy Includes bibliographical references. The diamino-diamide ligands have been investigated in an attempt to develop an antirheumatic drug. The ligands N,N'-di-(2-dimethylamino)ethyloxamide and N,N'di-(2-diethylamino)ethyloxamide, were synthesised and characterised using the physical techniques, NMR, mass- and infrared spectrometry. The stability constants of the complexes of Mg, Ca, Zn and several first transition metal-ions with the ligands were determined potentiometrically. The solution conformation of the CuII complexes were determined using visible spectrophotometry. Finally the physico-chemical studies were carried out. Firstly by studying the interaction of the copper complex with albumin at the physiological pH 7.4 using visible spectrophotometry. Secondly by determining the superoxide dismutase activity of the ligand by reduction of nitrobluetetrazolium using visible spectrophotometry. Lastly the ligands and the carr, CuII, MgII and ZnII metalions were monitored in vitro using the computer blood plasma model. 2016-02-22T07:20:48Z 2016-02-22T07:20:48Z 1988 Doctoral Thesis Doctoral PhD http://hdl.handle.net/11427/17187 eng application/pdf Department of Chemistry Faculty of Science University of Cape Town |
| spellingShingle | Antirheumatic Agents Rheumatism - Chemotherapy Voyi, Kuku Vinolia Vuyelwa Development of an antirheumatic drug |
| thesis_degree_str | Doctoral |
| title | Development of an antirheumatic drug |
| title_full | Development of an antirheumatic drug |
| title_fullStr | Development of an antirheumatic drug |
| title_full_unstemmed | Development of an antirheumatic drug |
| title_short | Development of an antirheumatic drug |
| title_sort | development of an antirheumatic drug |
| topic | Antirheumatic Agents Rheumatism - Chemotherapy |
| url | http://hdl.handle.net/11427/17187 |
| work_keys_str_mv | AT voyikukuvinoliavuyelwa developmentofanantirheumaticdrug |