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Transition metal complexes of tetracyclines
Forty-one transition metals were studied to observe their complexing properties with the tetracyclines. Four metals were found to form sufficiently strong complexes with the tetracyclines to provide a basis for a rapid, reliable method of assaying the potency of the tetracycline products used in med...
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| Format: | Thesis |
| Language: | English |
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Department of Chemistry
2016
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| _version_ | 1867613293342883841 |
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| access_status_str | Open Access |
| author | Cunningham, David Graham |
| author2 | Pay, M H |
| author_browse | Cunningham, David Graham Pay, M H |
| author_facet | Pay, M H Cunningham, David Graham |
| author_sort | Cunningham, David Graham |
| collection | Thesis |
| description | Forty-one transition metals were studied to observe their complexing properties with the tetracyclines. Four metals were found to form sufficiently strong complexes with the tetracyclines to provide a basis for a rapid, reliable method of assaying the potency of the tetracycline products used in medicine today. Microbiological methods take twenty hours to perform; spectrophotometric methods may be completed within one hour. Twenty-eight of the transition metals showed evidence of complex formation with the tetracyclines; not all of these complexes were found to be suitable for the spectrophotometric assay of the tetracyclines, however. The ligand-metal ratios of some of the transition metal-tetracycline complexes were determined under specified conditions using Job's method. In the concentration range for ligand and metal (3 x 10⁻⁵ M), the 1 : 1 complexes appeared to predominate. Attempts were made to identify the binding sites of the metal ions on the tetracycline molecules, using infra-red spectrophotometry, but the results were inconclusive. The stability constant of one of the transition metal-tetracycline complexes was determined by a potentiometric method. Using this method, the result for the titanium-tetracycline complex was β₁= 3,4 x 10¹⁵ M⁻¹. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/17731 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:33:49.949Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2016 |
| publishDateRange | 2016 |
| publishDateSort | 2016 |
| publisher | Department of Chemistry |
| publisherStr | Department of Chemistry |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/17731 Transition metal complexes of tetracyclines Cunningham, David Graham Pay, M H Fazakerley, G V Chemistry Forty-one transition metals were studied to observe their complexing properties with the tetracyclines. Four metals were found to form sufficiently strong complexes with the tetracyclines to provide a basis for a rapid, reliable method of assaying the potency of the tetracycline products used in medicine today. Microbiological methods take twenty hours to perform; spectrophotometric methods may be completed within one hour. Twenty-eight of the transition metals showed evidence of complex formation with the tetracyclines; not all of these complexes were found to be suitable for the spectrophotometric assay of the tetracyclines, however. The ligand-metal ratios of some of the transition metal-tetracycline complexes were determined under specified conditions using Job's method. In the concentration range for ligand and metal (3 x 10⁻⁵ M), the 1 : 1 complexes appeared to predominate. Attempts were made to identify the binding sites of the metal ions on the tetracycline molecules, using infra-red spectrophotometry, but the results were inconclusive. The stability constant of one of the transition metal-tetracycline complexes was determined by a potentiometric method. Using this method, the result for the titanium-tetracycline complex was β₁= 3,4 x 10¹⁵ M⁻¹. 2016-03-14T07:22:47Z 2016-03-14T07:22:47Z 1973 Master Thesis Masters MSc http://hdl.handle.net/11427/17731 eng application/pdf Department of Chemistry Faculty of Science University of Cape Town |
| spellingShingle | Chemistry Cunningham, David Graham Transition metal complexes of tetracyclines |
| thesis_degree_str | Master's |
| title | Transition metal complexes of tetracyclines |
| title_full | Transition metal complexes of tetracyclines |
| title_fullStr | Transition metal complexes of tetracyclines |
| title_full_unstemmed | Transition metal complexes of tetracyclines |
| title_short | Transition metal complexes of tetracyclines |
| title_sort | transition metal complexes of tetracyclines |
| topic | Chemistry |
| url | http://hdl.handle.net/11427/17731 |
| work_keys_str_mv | AT cunninghamdavidgraham transitionmetalcomplexesoftetracyclines |