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The interaction of some halogenated anaesthetic agents with hepatic drug metabolizing enzymes
Bibliography: pages 183-200.
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| Main Author: | |
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
| Published: |
Division of Medical Biochemistry
2016
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| _version_ | 1867613247988826112 |
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| access_status_str | Open Access |
| author | Marsh, Julia Anne |
| author2 | Ivanetich, Kathryn |
| author_browse | Ivanetich, Kathryn Marsh, Julia Anne |
| author_facet | Ivanetich, Kathryn Marsh, Julia Anne |
| author_sort | Marsh, Julia Anne |
| collection | Thesis |
| description | Bibliography: pages 183-200. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/18081 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:33:07.122Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2016 |
| publishDateRange | 2016 |
| publishDateSort | 2016 |
| publisher | Division of Medical Biochemistry |
| publisherStr | Division of Medical Biochemistry |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/18081 The interaction of some halogenated anaesthetic agents with hepatic drug metabolizing enzymes Marsh, Julia Anne Ivanetich, Kathryn Medical Biochemistry Bibliography: pages 183-200. This thesis comprises a report of investigations into the interaction of the volatile anaesthetic agents, fluroxene, 2,2,2-trifluoroethyl ethyl ether(TFEE), methoxyflurane and enflurane, with hepatic drug metabolizing enzymes in vivo and in vitro. Each of the anaesthetic agents interacts with the type P-450 cytochromes of hepatic microsomes in vitro resulting in the appearance of a type I difference spectrum, enhancement of NADPH oxidation and production of potentially toxic metabolites, 2,2,2-trifluoroethanol (TFE) (from fluroxene and TFEE) and free fluoride ion (from methoxyflurane and enflurane). 2016-03-21T19:19:24Z 2016-03-21T19:19:24Z 1977 Doctoral Thesis Doctoral PhD http://hdl.handle.net/11427/18081 eng application/pdf Division of Medical Biochemistry Faculty of Health Sciences University of Cape Town |
| spellingShingle | Medical Biochemistry Marsh, Julia Anne The interaction of some halogenated anaesthetic agents with hepatic drug metabolizing enzymes |
| thesis_degree_str | Doctoral |
| title | The interaction of some halogenated anaesthetic agents with hepatic drug metabolizing enzymes |
| title_full | The interaction of some halogenated anaesthetic agents with hepatic drug metabolizing enzymes |
| title_fullStr | The interaction of some halogenated anaesthetic agents with hepatic drug metabolizing enzymes |
| title_full_unstemmed | The interaction of some halogenated anaesthetic agents with hepatic drug metabolizing enzymes |
| title_short | The interaction of some halogenated anaesthetic agents with hepatic drug metabolizing enzymes |
| title_sort | interaction of some halogenated anaesthetic agents with hepatic drug metabolizing enzymes |
| topic | Medical Biochemistry |
| url | http://hdl.handle.net/11427/18081 |
| work_keys_str_mv | AT marshjuliaanne theinteractionofsomehalogenatedanaestheticagentswithhepaticdrugmetabolizingenzymes AT marshjuliaanne interactionofsomehalogenatedanaestheticagentswithhepaticdrugmetabolizingenzymes |