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Rhizophoraceae alkaloids : studies in the synthesis of Gerrardine
Gerrardine, an alkaloid isolated from Cassipourea gerrardii was previously established as 1-methyl-2,5-bis( 4'-hydroxy-1',2'-dithiolan-3'-yl)-pyrrolidine. The aim of the present research was to study the ways in which 1-methyl-2-(4'-hydroxy-1', 2'-dithiolan-3'-yl)-pyrrolidine, as a model compoun...
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| Format: | Thesis |
| Language: | English |
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Department of Chemistry
2016
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| _version_ | 1867613224417886208 |
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| access_status_str | Open Access |
| author | Kleynhans, Carl Rudolf |
| author2 | Warren, F L |
| author_browse | Kleynhans, Carl Rudolf Warren, F L |
| author_facet | Warren, F L Kleynhans, Carl Rudolf |
| author_sort | Kleynhans, Carl Rudolf |
| collection | Thesis |
| description | Gerrardine, an alkaloid isolated from Cassipourea gerrardii was previously established as 1-methyl-2,5-bis( 4'-hydroxy-1',2'-dithiolan-3'-yl)-pyrrolidine. The aim of the present research was to study the ways in which 1-methyl-2-(4'-hydroxy-1', 2'-dithiolan-3'-yl)-pyrrolidine, as a model compound could be synthesised since it contained asymmetric centres corresponding to those of gerrardine. The work resolved itself into attempts at the synthesis of 3-(1'-methylpyrrolidin-2'-yl)-1,3-dithiolpropan-2-ol since this would be converted into the required dithiolane by mild oxidation. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/18379 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:32:44.899Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2016 |
| publishDateRange | 2016 |
| publishDateSort | 2016 |
| publisher | Department of Chemistry |
| publisherStr | Department of Chemistry |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/18379 Rhizophoraceae alkaloids : studies in the synthesis of Gerrardine Kleynhans, Carl Rudolf Warren, F L Chemistry Gerrardine, an alkaloid isolated from Cassipourea gerrardii was previously established as 1-methyl-2,5-bis( 4'-hydroxy-1',2'-dithiolan-3'-yl)-pyrrolidine. The aim of the present research was to study the ways in which 1-methyl-2-(4'-hydroxy-1', 2'-dithiolan-3'-yl)-pyrrolidine, as a model compound could be synthesised since it contained asymmetric centres corresponding to those of gerrardine. The work resolved itself into attempts at the synthesis of 3-(1'-methylpyrrolidin-2'-yl)-1,3-dithiolpropan-2-ol since this would be converted into the required dithiolane by mild oxidation. 2016-03-30T07:11:37Z 2016-03-30T07:11:37Z 1972 Doctoral Thesis Doctoral PhD http://hdl.handle.net/11427/18379 eng application/pdf Department of Chemistry Faculty of Science University of Cape Town |
| spellingShingle | Chemistry Kleynhans, Carl Rudolf Rhizophoraceae alkaloids : studies in the synthesis of Gerrardine |
| thesis_degree_str | Doctoral |
| title | Rhizophoraceae alkaloids : studies in the synthesis of Gerrardine |
| title_full | Rhizophoraceae alkaloids : studies in the synthesis of Gerrardine |
| title_fullStr | Rhizophoraceae alkaloids : studies in the synthesis of Gerrardine |
| title_full_unstemmed | Rhizophoraceae alkaloids : studies in the synthesis of Gerrardine |
| title_short | Rhizophoraceae alkaloids : studies in the synthesis of Gerrardine |
| title_sort | rhizophoraceae alkaloids studies in the synthesis of gerrardine |
| topic | Chemistry |
| url | http://hdl.handle.net/11427/18379 |
| work_keys_str_mv | AT kleynhanscarlrudolf rhizophoraceaealkaloidsstudiesinthesynthesisofgerrardine |