Full Text Available
Note: Clicking the button above will open the full text document at the original institutional repository in a new window.
Outcomes of Human Immunodeficiency Virus infected children admitted to a paediatric intensive care unit in Cape Town, South Africa
During the mid to late 1990's, nearly all HIV infected children admitted to South African paediatric intensive care units died. This was in the context of an increasing HIV epidemic in Sub-Saharan Africa, a limited number of intensive care beds in public hospitals and the South African government re...
Saved in:
| Main Author: | |
|---|---|
| Other Authors: | |
| Format: | Thesis |
| Language: | English |
| Published: |
Department of Paediatrics and Child Health
2016
|
| Subjects: | |
| Tags: |
No Tags, Be the first to tag this record!
|
| _version_ | 1867613173721333760 |
|---|---|
| access_status_str | Open Access |
| author | Salie, Mogamat Shamiel |
| author2 | Argent, Andrew C |
| author_browse | Argent, Andrew C Salie, Mogamat Shamiel |
| author_facet | Argent, Andrew C Salie, Mogamat Shamiel |
| author_sort | Salie, Mogamat Shamiel |
| collection | Thesis |
| description | During the mid to late 1990's, nearly all HIV infected children admitted to South African paediatric intensive care units died. This was in the context of an increasing HIV epidemic in Sub-Saharan Africa, a limited number of intensive care beds in public hospitals and the South African government refusing to supply antiretroviral medication to public sector patients. HIV infected children all die without ARV medication, and it resulted in an increase in the South African under-5 mortality rate. In this context critically ill HIV infected children were often denied PICU admission. Developed countries introduced ARV medication in the early 1990's and the South African government only started supplying ARV medication in late 2003. When ARV medication became available in South Africa, it was started on the basis of the individual child's clinical and immunological status and there was not much published data on initiation of ARV therapy in critical ill children in intensive care units. Many HIV infected children had recurrent hospital admissions and many children died before initiating ARV medication. HIV infected children are not only susceptible to the normal bacteria and viruses, but at increased risk of opportunistic and mycobacterial infections. CMV has increasingly been recognized as a common co-infection with PCP, but has been difficult to diagnose and treat effectively. We retrospectively reviewed all HIV exposed and infected children admitted to our PICU in 2009. In addition to our standard treatment, we initiated ARV medication as soon as logistically possible and children with suspected CMV infections were empirically treated with gancyclovir. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/19900 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:31:56.645Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2016 |
| publishDateRange | 2016 |
| publishDateSort | 2016 |
| publisher | Department of Paediatrics and Child Health |
| publisherStr | Department of Paediatrics and Child Health |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/19900 Outcomes of Human Immunodeficiency Virus infected children admitted to a paediatric intensive care unit in Cape Town, South Africa Salie, Mogamat Shamiel Argent, Andrew C Clinical Research During the mid to late 1990's, nearly all HIV infected children admitted to South African paediatric intensive care units died. This was in the context of an increasing HIV epidemic in Sub-Saharan Africa, a limited number of intensive care beds in public hospitals and the South African government refusing to supply antiretroviral medication to public sector patients. HIV infected children all die without ARV medication, and it resulted in an increase in the South African under-5 mortality rate. In this context critically ill HIV infected children were often denied PICU admission. Developed countries introduced ARV medication in the early 1990's and the South African government only started supplying ARV medication in late 2003. When ARV medication became available in South Africa, it was started on the basis of the individual child's clinical and immunological status and there was not much published data on initiation of ARV therapy in critical ill children in intensive care units. Many HIV infected children had recurrent hospital admissions and many children died before initiating ARV medication. HIV infected children are not only susceptible to the normal bacteria and viruses, but at increased risk of opportunistic and mycobacterial infections. CMV has increasingly been recognized as a common co-infection with PCP, but has been difficult to diagnose and treat effectively. We retrospectively reviewed all HIV exposed and infected children admitted to our PICU in 2009. In addition to our standard treatment, we initiated ARV medication as soon as logistically possible and children with suspected CMV infections were empirically treated with gancyclovir. 2016-06-02T08:48:01Z 2016-06-02T08:48:01Z 2015 Master Thesis Masters MPH http://hdl.handle.net/11427/19900 eng application/pdf Department of Paediatrics and Child Health Faculty of Health Sciences University of Cape Town |
| spellingShingle | Clinical Research Salie, Mogamat Shamiel Outcomes of Human Immunodeficiency Virus infected children admitted to a paediatric intensive care unit in Cape Town, South Africa |
| thesis_degree_str | Master's |
| title | Outcomes of Human Immunodeficiency Virus infected children admitted to a paediatric intensive care unit in Cape Town, South Africa |
| title_full | Outcomes of Human Immunodeficiency Virus infected children admitted to a paediatric intensive care unit in Cape Town, South Africa |
| title_fullStr | Outcomes of Human Immunodeficiency Virus infected children admitted to a paediatric intensive care unit in Cape Town, South Africa |
| title_full_unstemmed | Outcomes of Human Immunodeficiency Virus infected children admitted to a paediatric intensive care unit in Cape Town, South Africa |
| title_short | Outcomes of Human Immunodeficiency Virus infected children admitted to a paediatric intensive care unit in Cape Town, South Africa |
| title_sort | outcomes of human immunodeficiency virus infected children admitted to a paediatric intensive care unit in cape town south africa |
| topic | Clinical Research |
| url | http://hdl.handle.net/11427/19900 |
| work_keys_str_mv | AT saliemogamatshamiel outcomesofhumanimmunodeficiencyvirusinfectedchildrenadmittedtoapaediatricintensivecareunitincapetownsouthafrica |