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A topic model based approach to inferring episodic directional selection in protein coding sequences
Pathogens, such as HIV and influenza, evolve in response to the selective pressures of their host environments accumulating changes in their genomes that offer fitness benefits. This selective pressure is characterised by three properties: (1.) it is episodic, tracking changes in the adaptive immune...
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| Format: | Thesis |
| Language: | English |
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Department of Statistical Sciences
2016
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