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Radiological progression of lung disease in Human Immunodeficiency Virus (HIV)-infected children
Introduction: There are limited data on the chest X-ray (CXR) abnormalities in human immunodeficiency virus (HIV)-infected children in low- and middle-income countries (LMIC's). Aim: To investigate the evolution of CXR abnormalities in HIV-infected children in LMIC's, to correlate this with the se...
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| Format: | Thesis |
| Language: | English |
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Department of Paediatrics and Child Health
2016
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| _version_ | 1867613320415019008 |
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| access_status_str | Open Access |
| author | Pitcher, Richard D |
| author2 | Zar, Heather |
| author_browse | Pitcher, Richard D Zar, Heather |
| author_facet | Zar, Heather Pitcher, Richard D |
| author_sort | Pitcher, Richard D |
| collection | Thesis |
| description | Introduction: There are limited data on the chest X-ray (CXR) abnormalities in human immunodeficiency virus (HIV)-infected children in low- and middle-income countries (LMIC's). Aim: To investigate the evolution of CXR abnormalities in HIV-infected children in LMIC's, to correlate this with the severity of HIV-disease, and to assess the impact of anti-retroviral therapy (ART). Method: A prospective longitudinal study evaluating clinical, immunological and radiographic parameters at regular intervals over a minimum of 24 months. CXR abnormalities were stratified by severity and deemed persistent if present for 6 consecutive months or longer. Univariate and multiple logistic regression analyses assessed associations between radiological and clinical/immunological parameters at enrolment. An ordinal multiple logistic regression model assessed the association of enrolment and time-dependent variables with CXR findings over time. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/20351 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:34:14.045Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2016 |
| publishDateRange | 2016 |
| publishDateSort | 2016 |
| publisher | Department of Paediatrics and Child Health |
| publisherStr | Department of Paediatrics and Child Health |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/20351 Radiological progression of lung disease in Human Immunodeficiency Virus (HIV)-infected children Pitcher, Richard D Zar, Heather Paediatrics and Child Health Introduction: There are limited data on the chest X-ray (CXR) abnormalities in human immunodeficiency virus (HIV)-infected children in low- and middle-income countries (LMIC's). Aim: To investigate the evolution of CXR abnormalities in HIV-infected children in LMIC's, to correlate this with the severity of HIV-disease, and to assess the impact of anti-retroviral therapy (ART). Method: A prospective longitudinal study evaluating clinical, immunological and radiographic parameters at regular intervals over a minimum of 24 months. CXR abnormalities were stratified by severity and deemed persistent if present for 6 consecutive months or longer. Univariate and multiple logistic regression analyses assessed associations between radiological and clinical/immunological parameters at enrolment. An ordinal multiple logistic regression model assessed the association of enrolment and time-dependent variables with CXR findings over time. 2016-07-14T12:23:02Z 2016-07-14T12:23:02Z 2016 Doctoral Thesis Doctoral PhD http://hdl.handle.net/11427/20351 eng application/pdf Department of Paediatrics and Child Health Faculty of Health Sciences University of Cape Town |
| spellingShingle | Paediatrics and Child Health Pitcher, Richard D Radiological progression of lung disease in Human Immunodeficiency Virus (HIV)-infected children |
| thesis_degree_str | Doctoral |
| title | Radiological progression of lung disease in Human Immunodeficiency Virus (HIV)-infected children |
| title_full | Radiological progression of lung disease in Human Immunodeficiency Virus (HIV)-infected children |
| title_fullStr | Radiological progression of lung disease in Human Immunodeficiency Virus (HIV)-infected children |
| title_full_unstemmed | Radiological progression of lung disease in Human Immunodeficiency Virus (HIV)-infected children |
| title_short | Radiological progression of lung disease in Human Immunodeficiency Virus (HIV)-infected children |
| title_sort | radiological progression of lung disease in human immunodeficiency virus hiv infected children |
| topic | Paediatrics and Child Health |
| url | http://hdl.handle.net/11427/20351 |
| work_keys_str_mv | AT pitcherrichardd radiologicalprogressionoflungdiseaseinhumanimmunodeficiencyvirushivinfectedchildren |