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Preconception maternal exposure to Nippostrongylus brasiliensis transfers protection against Nb to her offspring

In early life the immature immune system has a reduced ability to control infection. This susceptibility is offset by transfer of protective immune components from the mother. Helminth infections are widespread and can have a long lasting influence on host immunity. Children of mothers exposed to he...

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Main Author: Darby, Matthew G
Other Authors: Horsnell, William
Format: Thesis
Language:English
Published: Institute of Infectious Disease and Molecular Medicine 2016
Subjects:
Infectious Disease and Molecular Medicine
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access_status_str Open Access
author Darby, Matthew G
author2 Horsnell, William
author_browse Darby, Matthew G
Horsnell, William
author_facet Horsnell, William
Darby, Matthew G
author_sort Darby, Matthew G
collection Thesis
description In early life the immature immune system has a reduced ability to control infection. This susceptibility is offset by transfer of protective immune components from the mother. Helminth infections are widespread and can have a long lasting influence on host immunity. Children of mothers exposed to helminth infections may display T cell sensitization to endemic helminth infections and associations have been made between maternal helminth infection and altered immune responses to childhood diseases and vaccinations. This shows that helminth-modified maternal immunity may imprint on early offspring immune development in-utero or through breast milk in the form of transfer of, for example, antibodies, cytokines and lymphocytes. Our study shows that, in mice, maternal infection with the helminth Nippostrongylus brasiliensis is not only associated with a passive transfer of antigen specific antibody(IgG1) but also inherently alters offspring immunity, increasing offspring cytokine production, alveolar macrophages, lung neutrophils and B cell population development and proliferation. Pups born to N. brasiliensis exposed mothers also had increased populations of lung and spleen CD4+ cells and higher subpopulations of central memory and effector CD4+ cells compared to pups born to naive mothers.
format Thesis
id oai:open.uct.ac.za:11427/20410
institution University of Cape Town (South Africa)
language eng
last_indexed 2026-06-10T12:32:26.116Z
license_str Not specified — see source repository
provenance_str_mv Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository
publishDate 2016
publishDateRange 2016
publishDateSort 2016
publisher Institute of Infectious Disease and Molecular Medicine
publisherStr Institute of Infectious Disease and Molecular Medicine
record_format dspace
source_str UCTD — University of Cape Town Open Access Repository
spelling oai:open.uct.ac.za:11427/20410 Preconception maternal exposure to Nippostrongylus brasiliensis transfers protection against Nb to her offspring Darby, Matthew G Horsnell, William Brombacher, Frank Infectious Disease and Molecular Medicine In early life the immature immune system has a reduced ability to control infection. This susceptibility is offset by transfer of protective immune components from the mother. Helminth infections are widespread and can have a long lasting influence on host immunity. Children of mothers exposed to helminth infections may display T cell sensitization to endemic helminth infections and associations have been made between maternal helminth infection and altered immune responses to childhood diseases and vaccinations. This shows that helminth-modified maternal immunity may imprint on early offspring immune development in-utero or through breast milk in the form of transfer of, for example, antibodies, cytokines and lymphocytes. Our study shows that, in mice, maternal infection with the helminth Nippostrongylus brasiliensis is not only associated with a passive transfer of antigen specific antibody(IgG1) but also inherently alters offspring immunity, increasing offspring cytokine production, alveolar macrophages, lung neutrophils and B cell population development and proliferation. Pups born to N. brasiliensis exposed mothers also had increased populations of lung and spleen CD4+ cells and higher subpopulations of central memory and effector CD4+ cells compared to pups born to naive mothers. 2016-07-18T12:44:42Z 2016-07-18T12:44:42Z 2016 Doctoral Thesis Doctoral PhD http://hdl.handle.net/11427/20410 eng application/pdf Institute of Infectious Disease and Molecular Medicine Faculty of Health Sciences University of Cape Town
spellingShingle Infectious Disease and Molecular Medicine
Darby, Matthew G
Preconception maternal exposure to Nippostrongylus brasiliensis transfers protection against Nb to her offspring
thesis_degree_str Doctoral
title Preconception maternal exposure to Nippostrongylus brasiliensis transfers protection against Nb to her offspring
title_full Preconception maternal exposure to Nippostrongylus brasiliensis transfers protection against Nb to her offspring
title_fullStr Preconception maternal exposure to Nippostrongylus brasiliensis transfers protection against Nb to her offspring
title_full_unstemmed Preconception maternal exposure to Nippostrongylus brasiliensis transfers protection against Nb to her offspring
title_short Preconception maternal exposure to Nippostrongylus brasiliensis transfers protection against Nb to her offspring
title_sort preconception maternal exposure to nippostrongylus brasiliensis transfers protection against nb to her offspring
topic Infectious Disease and Molecular Medicine
url http://hdl.handle.net/11427/20410
work_keys_str_mv AT darbymatthewg preconceptionmaternalexposuretonippostrongylusbrasiliensistransfersprotectionagainstnbtoheroffspring

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