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Early morning urine collection to improve the sensitivity of LAM in hospitalised TB/HIV co-infected patients
Point-of-care detection of urine lipoarabinomannan (LAM) is a low-cost rapid TB diagnostic for use in HIV co-infected patients. However, its sensitivity in these patients is suboptimal. Strategies to improve its performance is a need. The hypothesis was that early morning urine (EMU), rather than ra...
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| Format: | Thesis |
| Language: | English |
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Division of Pulmonology
2016
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| _version_ | 1867613244781232129 |
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| access_status_str | Open Access |
| author | Gina, Ntombenhle Phindile |
| author2 | Dheda, Keertan |
| author_browse | Dheda, Keertan Gina, Ntombenhle Phindile |
| author_facet | Dheda, Keertan Gina, Ntombenhle Phindile |
| author_sort | Gina, Ntombenhle Phindile |
| collection | Thesis |
| description | Point-of-care detection of urine lipoarabinomannan (LAM) is a low-cost rapid TB diagnostic for use in HIV co-infected patients. However, its sensitivity in these patients is suboptimal. Strategies to improve its performance is a need. The hypothesis was that early morning urine (EMU), rather than random urine sampling, would improve LAM's sensitivity. Methods Recruitment process conducted between June 2012 and February 2014 for HIV-infected patients from four hospitals in Cape Town, South Africa presenting with possible TB (all patients initiated on TB treatment). Fresh random and early morning urine (EMU) samples (~10-30 ml) collected in sterile containers. Following the manufacturer's instructions, an Alere Determine® TB Lateral flow assay performed on each sample, using both grade 1 and 2 cut-points. A single sputum Xpert MTB/RIF and/or liquid TB culture was a reference standard. Those designated probable TB patients were sputum Xpert MTB/RIF and/ TB culture negative, but started on TB treatment. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/20834 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:33:04.194Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2016 |
| publishDateRange | 2016 |
| publishDateSort | 2016 |
| publisher | Division of Pulmonology |
| publisherStr | Division of Pulmonology |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/20834 Early morning urine collection to improve the sensitivity of LAM in hospitalised TB/HIV co-infected patients Gina, Ntombenhle Phindile Dheda, Keertan Peter, Jonathan G Randall, Philippa Internal Medicine Point-of-care detection of urine lipoarabinomannan (LAM) is a low-cost rapid TB diagnostic for use in HIV co-infected patients. However, its sensitivity in these patients is suboptimal. Strategies to improve its performance is a need. The hypothesis was that early morning urine (EMU), rather than random urine sampling, would improve LAM's sensitivity. Methods Recruitment process conducted between June 2012 and February 2014 for HIV-infected patients from four hospitals in Cape Town, South Africa presenting with possible TB (all patients initiated on TB treatment). Fresh random and early morning urine (EMU) samples (~10-30 ml) collected in sterile containers. Following the manufacturer's instructions, an Alere Determine® TB Lateral flow assay performed on each sample, using both grade 1 and 2 cut-points. A single sputum Xpert MTB/RIF and/or liquid TB culture was a reference standard. Those designated probable TB patients were sputum Xpert MTB/RIF and/ TB culture negative, but started on TB treatment. 2016-07-27T10:13:35Z 2016-07-27T10:13:35Z 2016 Master Thesis Masters MMed http://hdl.handle.net/11427/20834 eng application/pdf Division of Pulmonology Faculty of Health Sciences University of Cape Town |
| spellingShingle | Internal Medicine Gina, Ntombenhle Phindile Early morning urine collection to improve the sensitivity of LAM in hospitalised TB/HIV co-infected patients |
| thesis_degree_str | Master's |
| title | Early morning urine collection to improve the sensitivity of LAM in hospitalised TB/HIV co-infected patients |
| title_full | Early morning urine collection to improve the sensitivity of LAM in hospitalised TB/HIV co-infected patients |
| title_fullStr | Early morning urine collection to improve the sensitivity of LAM in hospitalised TB/HIV co-infected patients |
| title_full_unstemmed | Early morning urine collection to improve the sensitivity of LAM in hospitalised TB/HIV co-infected patients |
| title_short | Early morning urine collection to improve the sensitivity of LAM in hospitalised TB/HIV co-infected patients |
| title_sort | early morning urine collection to improve the sensitivity of lam in hospitalised tb hiv co infected patients |
| topic | Internal Medicine |
| url | http://hdl.handle.net/11427/20834 |
| work_keys_str_mv | AT ginantombenhlephindile earlymorningurinecollectiontoimprovethesensitivityoflaminhospitalisedtbhivcoinfectedpatients |