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Rapid review of drug management for paediatric seizure termination in the emergency setting
Prolonged seizures are a medical emergency and require immediate treatment to prevent complications. Benzodiazepines (BDZ's) are integral to acute seizure management. The most commonly used BDZs are Lorazepam, Diazepam and Midazolam. Lorazepam is often perceived as the superior choice but recent stu...
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| Format: | Thesis |
| Language: | English |
| Published: |
Division of Emergency Medicine
2016
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| _version_ | 1867613251397746688 |
|---|---|
| access_status_str | Open Access |
| author | Stockigt, Jeannie Claudette |
| author_browse | Stockigt, Jeannie Claudette |
| author_facet | Stockigt, Jeannie Claudette |
| author_sort | Stockigt, Jeannie Claudette |
| collection | Thesis |
| description | Prolonged seizures are a medical emergency and require immediate treatment to prevent complications. Benzodiazepines (BDZ's) are integral to acute seizure management. The most commonly used BDZs are Lorazepam, Diazepam and Midazolam. Lorazepam is often perceived as the superior choice but recent studies have challenged this but results appear inconclusive and contradictory. This study aims to consolidate the available literature and formulate recommendations for the use of BDZs in the emergency setting for children. Methods A rapid review methodology with a tiered approach was used. This approach uses high quality guidelines as the first tier, review of reviews (second tier) then systematic reviews and the fourth and final tier uses randomized control trials as primary data. The Australian National Health Medical Research Council's matrix for grading and developing guidelines was used to grade quality of recommendations. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/20929 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:33:10.259Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2016 |
| publishDateRange | 2016 |
| publishDateSort | 2016 |
| publisher | Division of Emergency Medicine |
| publisherStr | Division of Emergency Medicine |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/20929 Rapid review of drug management for paediatric seizure termination in the emergency setting Stockigt, Jeannie Claudette Emergency Medicine Prolonged seizures are a medical emergency and require immediate treatment to prevent complications. Benzodiazepines (BDZ's) are integral to acute seizure management. The most commonly used BDZs are Lorazepam, Diazepam and Midazolam. Lorazepam is often perceived as the superior choice but recent studies have challenged this but results appear inconclusive and contradictory. This study aims to consolidate the available literature and formulate recommendations for the use of BDZs in the emergency setting for children. Methods A rapid review methodology with a tiered approach was used. This approach uses high quality guidelines as the first tier, review of reviews (second tier) then systematic reviews and the fourth and final tier uses randomized control trials as primary data. The Australian National Health Medical Research Council's matrix for grading and developing guidelines was used to grade quality of recommendations. 2016-07-28T11:23:13Z 2016-07-28T11:23:13Z 2016 Master Thesis Masters MPhil http://hdl.handle.net/11427/20929 eng application/pdf Division of Emergency Medicine Faculty of Health Sciences University of Cape Town |
| spellingShingle | Emergency Medicine Stockigt, Jeannie Claudette Rapid review of drug management for paediatric seizure termination in the emergency setting |
| thesis_degree_str | Master's |
| title | Rapid review of drug management for paediatric seizure termination in the emergency setting |
| title_full | Rapid review of drug management for paediatric seizure termination in the emergency setting |
| title_fullStr | Rapid review of drug management for paediatric seizure termination in the emergency setting |
| title_full_unstemmed | Rapid review of drug management for paediatric seizure termination in the emergency setting |
| title_short | Rapid review of drug management for paediatric seizure termination in the emergency setting |
| title_sort | rapid review of drug management for paediatric seizure termination in the emergency setting |
| topic | Emergency Medicine |
| url | http://hdl.handle.net/11427/20929 |
| work_keys_str_mv | AT stockigtjeannieclaudette rapidreviewofdrugmanagementforpaediatricseizureterminationintheemergencysetting |