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Structures and thermal decompositions of pseudopolymorphs of sulfonamide drugs
Pseudopolymorphs of two sulfonamide drugs, namely sulfathiazole and succinylsulfathiazole, have been prepared by recrystallization of the drugs from various organic solvents and their properties have been studied by several physicochemical methods. Thermal Analysis involving Thermal Gravimetry (TG)...
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| Format: | Thesis |
| Language: | English |
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Department of Chemistry
2016
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| _version_ | 1867613344192528384 |
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| access_status_str | Open Access |
| author | Shabalala, Innocent Philani |
| author2 | Caira, Mino R |
| author_browse | Caira, Mino R Shabalala, Innocent Philani |
| author_facet | Caira, Mino R Shabalala, Innocent Philani |
| author_sort | Shabalala, Innocent Philani |
| collection | Thesis |
| description | Pseudopolymorphs of two sulfonamide drugs, namely sulfathiazole and succinylsulfathiazole, have been prepared by recrystallization of the drugs from various organic solvents and their properties have been studied by several physicochemical methods. Thermal Analysis involving Thermal Gravimetry (TG) and Differential Scanning Calorimetry (DSC) were used to investigate such thermal properties of the crystals as stabilities, desolvation processes and their kinetics as well as the melting of pure polymorphic forms of the drugs resulting from desolvation. Complementary studies of the compounds using X-ray powder diffraction (XRD) and DSC allowed identification and assignment of the products of desolvation i.e. polymorphs. Single crystal studies were carried out by X-ray diffraction methods. Interesting structural features such as crystal packing modes, hydrogen bonding schemes, cavity versus channel occupation by guest molecules and host conformations were investigated. From a high level of agreement of results obtained using these methods, the pseudopolymorphs and polymorphs studied were characterized unambiguously. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/22056 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:34:39.078Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2016 |
| publishDateRange | 2016 |
| publishDateSort | 2016 |
| publisher | Department of Chemistry |
| publisherStr | Department of Chemistry |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/22056 Structures and thermal decompositions of pseudopolymorphs of sulfonamide drugs Shabalala, Innocent Philani Caira, Mino R Chemistry Pseudopolymorphs of two sulfonamide drugs, namely sulfathiazole and succinylsulfathiazole, have been prepared by recrystallization of the drugs from various organic solvents and their properties have been studied by several physicochemical methods. Thermal Analysis involving Thermal Gravimetry (TG) and Differential Scanning Calorimetry (DSC) were used to investigate such thermal properties of the crystals as stabilities, desolvation processes and their kinetics as well as the melting of pure polymorphic forms of the drugs resulting from desolvation. Complementary studies of the compounds using X-ray powder diffraction (XRD) and DSC allowed identification and assignment of the products of desolvation i.e. polymorphs. Single crystal studies were carried out by X-ray diffraction methods. Interesting structural features such as crystal packing modes, hydrogen bonding schemes, cavity versus channel occupation by guest molecules and host conformations were investigated. From a high level of agreement of results obtained using these methods, the pseudopolymorphs and polymorphs studied were characterized unambiguously. 2016-10-03T04:10:10Z 2016-10-03T04:10:10Z 1995 Master Thesis Masters MSc http://hdl.handle.net/11427/22056 eng application/pdf Department of Chemistry Faculty of Science University of Cape Town |
| spellingShingle | Chemistry Shabalala, Innocent Philani Structures and thermal decompositions of pseudopolymorphs of sulfonamide drugs |
| thesis_degree_str | Master's |
| title | Structures and thermal decompositions of pseudopolymorphs of sulfonamide drugs |
| title_full | Structures and thermal decompositions of pseudopolymorphs of sulfonamide drugs |
| title_fullStr | Structures and thermal decompositions of pseudopolymorphs of sulfonamide drugs |
| title_full_unstemmed | Structures and thermal decompositions of pseudopolymorphs of sulfonamide drugs |
| title_short | Structures and thermal decompositions of pseudopolymorphs of sulfonamide drugs |
| title_sort | structures and thermal decompositions of pseudopolymorphs of sulfonamide drugs |
| topic | Chemistry |
| url | http://hdl.handle.net/11427/22056 |
| work_keys_str_mv | AT shabalalainnocentphilani structuresandthermaldecompositionsofpseudopolymorphsofsulfonamidedrugs |