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The physicochemical characterisation of cyclodextrin inclusion compounds with non-steroidal anti-inflammatory drugs
The cyclodextrins and their derivatives have been utilised as complexing agents for a wide range of pharmaceutical compounds, through their ability to include small molecular weight molecules inside an annular cavity formed by linked glucose residues of varying number. The non-steroidal anti-inflamm...
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| Format: | Thesis |
| Language: | English |
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Department of Chemistry
2017
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| _version_ | 1867613265639505920 |
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| access_status_str | Open Access |
| author | Brown, Gavin Robert |
| author2 | Caira, Mino R |
| author_browse | Brown, Gavin Robert Caira, Mino R |
| author_facet | Caira, Mino R Brown, Gavin Robert |
| author_sort | Brown, Gavin Robert |
| collection | Thesis |
| description | The cyclodextrins and their derivatives have been utilised as complexing agents for a wide range of pharmaceutical compounds, through their ability to include small molecular weight molecules inside an annular cavity formed by linked glucose residues of varying number. The non-steroidal anti-inflammatory drugs (NSAIDs), a group of agents that share a similar therapeutic effect in the management of inflammatory processes in the body, have been studied as guest molecules for inclusion in cyclodextrins, due to a number of potential advantages that are conferred by complexation, such as improved bioavailability, modified side-effect profiles and the control of drug release from novel formulations. This study has tested a number of commonly used NSAIDs belonging to certain structural groups, together with a number of cyclodextrins and their derivatives, and attempts have been made to prepare complexes in the solid state and characterise them using physicochemical methods. The cyclodextrins used were native seven' and eight-membered β- and y-cyclodextrin and two methylated derivatives of β-cyclodextrin, namely heptakis(2,6-di-0-methyl)-β-cyclodextrin and heptakis(2,3,6- tri-O-methyl)-β-cyclodextrin, abbreviated as DIMES and TRIMEB respectively. NSAIDs belonging to the salicylate, fenamate, profen, oxicam and indene structural groups were used. These included diflunisal, mefenamic acid, niflumic acid, tolfenamic acid, flufenamic acid, ibuprofen, ketoprofen, piroxicam, tenoxicam, indomethacin and sulindac. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/23177 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:33:23.204Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2017 |
| publishDateRange | 2017 |
| publishDateSort | 2017 |
| publisher | Department of Chemistry |
| publisherStr | Department of Chemistry |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/23177 The physicochemical characterisation of cyclodextrin inclusion compounds with non-steroidal anti-inflammatory drugs Brown, Gavin Robert Caira, Mino R Nassimbeni, Luigi R Chemistry The cyclodextrins and their derivatives have been utilised as complexing agents for a wide range of pharmaceutical compounds, through their ability to include small molecular weight molecules inside an annular cavity formed by linked glucose residues of varying number. The non-steroidal anti-inflammatory drugs (NSAIDs), a group of agents that share a similar therapeutic effect in the management of inflammatory processes in the body, have been studied as guest molecules for inclusion in cyclodextrins, due to a number of potential advantages that are conferred by complexation, such as improved bioavailability, modified side-effect profiles and the control of drug release from novel formulations. This study has tested a number of commonly used NSAIDs belonging to certain structural groups, together with a number of cyclodextrins and their derivatives, and attempts have been made to prepare complexes in the solid state and characterise them using physicochemical methods. The cyclodextrins used were native seven' and eight-membered β- and y-cyclodextrin and two methylated derivatives of β-cyclodextrin, namely heptakis(2,6-di-0-methyl)-β-cyclodextrin and heptakis(2,3,6- tri-O-methyl)-β-cyclodextrin, abbreviated as DIMES and TRIMEB respectively. NSAIDs belonging to the salicylate, fenamate, profen, oxicam and indene structural groups were used. These included diflunisal, mefenamic acid, niflumic acid, tolfenamic acid, flufenamic acid, ibuprofen, ketoprofen, piroxicam, tenoxicam, indomethacin and sulindac. 2017-01-26T06:58:47Z 2017-01-26T06:58:47Z 1997 2016-11-22T09:12:07Z Thesis http://hdl.handle.net/11427/23177 eng application/pdf Department of Chemistry Faculty of Science University of Cape Town |
| spellingShingle | Chemistry Brown, Gavin Robert The physicochemical characterisation of cyclodextrin inclusion compounds with non-steroidal anti-inflammatory drugs |
| title | The physicochemical characterisation of cyclodextrin inclusion compounds with non-steroidal anti-inflammatory drugs |
| title_full | The physicochemical characterisation of cyclodextrin inclusion compounds with non-steroidal anti-inflammatory drugs |
| title_fullStr | The physicochemical characterisation of cyclodextrin inclusion compounds with non-steroidal anti-inflammatory drugs |
| title_full_unstemmed | The physicochemical characterisation of cyclodextrin inclusion compounds with non-steroidal anti-inflammatory drugs |
| title_short | The physicochemical characterisation of cyclodextrin inclusion compounds with non-steroidal anti-inflammatory drugs |
| title_sort | physicochemical characterisation of cyclodextrin inclusion compounds with non steroidal anti inflammatory drugs |
| topic | Chemistry |
| url | http://hdl.handle.net/11427/23177 |
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