Full Text Available
Note: Clicking the button above will open the full text document at the original institutional repository in a new window.
Cardiovascular magnetic resonance characterisation of myocardial involvement in tuberculous pericardial constriction with and without HIV co-infection
Background:Tuberculous pericarditis includes the spectrum of pericarditis caused by Mycobacterium tuberculosis manifesting with pericardial effusion, cardiac tamponade, effusive-constrictive and constrictive pericarditis. In patients with pericardial tuberculosis, co-infection with human immunodefic...
Saved in:
| Main Author: | |
|---|---|
| Other Authors: | |
| Format: | Thesis |
| Language: | English |
| Published: |
Department of Medicine
2017
|
| Subjects: | |
| Tags: |
No Tags, Be the first to tag this record!
|
| _version_ | 1867613954724855808 |
|---|---|
| access_status_str | Open Access |
| author | Palkowski, Gregori H |
| author2 | Ntusi, Ntobeko A B |
| author_browse | Ntusi, Ntobeko A B Palkowski, Gregori H |
| author_facet | Ntusi, Ntobeko A B Palkowski, Gregori H |
| author_sort | Palkowski, Gregori H |
| collection | Thesis |
| description | Background:Tuberculous pericarditis includes the spectrum of pericarditis caused by Mycobacterium tuberculosis manifesting with pericardial effusion, cardiac tamponade, effusive-constrictive and constrictive pericarditis. In patients with pericardial tuberculosis, co-infection with human immunodeficiency virus (HIV) is associated with increased incidence of haemodynamic instability, electrocardiographic (ECG) ST elevation and mortality, suggesting an aggressive myopericarditis. However, little is known about myocardial involvement in patients with pericardial tuberculosis. Cardiovascular magnetic resonance (CMR) can assess non-invasively cardiac function, myocardial oedema, inflammation and fibrosis. Objectives: To assess cardiac and pericardial structure and function in patients with TBPC with and without HIV co-infection and to assess the relationship of left ventricular (LV) function with other imaging biomarkers. Methods: 72 patients with TBPC (37 male (51.3%), mean age 40 ± 14.3) were included in the study. Of these, 35 were HIV infected (17 male (48.6%), mean age 34 ± 8) and 37 were HIV uninfected (20 male (54.1%), mean age 51 ± 16). Assessments included clinical examination, ECG, echocardiography, serum and pericardial biomarkers and CMR (biventricular volumes and function, oedema, and late gadolinium enhancement - LGE). Results: HIV infected TBPC patients were younger (p<0.001), had lower serum haemoglobin (p<0.001) and were more likely to have NYHA class III and IV symptoms (p<0.001). There were no differences on ECG and echocardiography between HIV infected and uninfected TBPC patients. There were also no differences in global systolic function between HIV infected and uninfected TBP patients. Focal fibrosis on LGE was found more commonly in those with HIV infection (p<0.001). Pericardial effusions were frequent (>50%) in both groups of TBPC patients. Determinants of LV ejection fraction in TBPC included heart rate, LV size, E/A ratio, pericardial LGE and pericardial thickness (all p<0.01). Conclusions: HIV co-infection is associated with increased focal myocardial fibrosis in TBPC patients suggesting increased myocardial inflammation in those with HIV co-infection. In the future, it will be important to assess the prognostic significance of these findings. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/23659 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:44:21.583Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2017 |
| publishDateRange | 2017 |
| publishDateSort | 2017 |
| publisher | Department of Medicine |
| publisherStr | Department of Medicine |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/23659 Cardiovascular magnetic resonance characterisation of myocardial involvement in tuberculous pericardial constriction with and without HIV co-infection Palkowski, Gregori H Ntusi, Ntobeko A B Medicine Background:Tuberculous pericarditis includes the spectrum of pericarditis caused by Mycobacterium tuberculosis manifesting with pericardial effusion, cardiac tamponade, effusive-constrictive and constrictive pericarditis. In patients with pericardial tuberculosis, co-infection with human immunodeficiency virus (HIV) is associated with increased incidence of haemodynamic instability, electrocardiographic (ECG) ST elevation and mortality, suggesting an aggressive myopericarditis. However, little is known about myocardial involvement in patients with pericardial tuberculosis. Cardiovascular magnetic resonance (CMR) can assess non-invasively cardiac function, myocardial oedema, inflammation and fibrosis. Objectives: To assess cardiac and pericardial structure and function in patients with TBPC with and without HIV co-infection and to assess the relationship of left ventricular (LV) function with other imaging biomarkers. Methods: 72 patients with TBPC (37 male (51.3%), mean age 40 ± 14.3) were included in the study. Of these, 35 were HIV infected (17 male (48.6%), mean age 34 ± 8) and 37 were HIV uninfected (20 male (54.1%), mean age 51 ± 16). Assessments included clinical examination, ECG, echocardiography, serum and pericardial biomarkers and CMR (biventricular volumes and function, oedema, and late gadolinium enhancement - LGE). Results: HIV infected TBPC patients were younger (p<0.001), had lower serum haemoglobin (p<0.001) and were more likely to have NYHA class III and IV symptoms (p<0.001). There were no differences on ECG and echocardiography between HIV infected and uninfected TBPC patients. There were also no differences in global systolic function between HIV infected and uninfected TBP patients. Focal fibrosis on LGE was found more commonly in those with HIV infection (p<0.001). Pericardial effusions were frequent (>50%) in both groups of TBPC patients. Determinants of LV ejection fraction in TBPC included heart rate, LV size, E/A ratio, pericardial LGE and pericardial thickness (all p<0.01). Conclusions: HIV co-infection is associated with increased focal myocardial fibrosis in TBPC patients suggesting increased myocardial inflammation in those with HIV co-infection. In the future, it will be important to assess the prognostic significance of these findings. 2017-01-27T14:21:44Z 2017-01-27T14:21:44Z 2016 Master Thesis Masters MMed http://hdl.handle.net/11427/23659 eng application/pdf Department of Medicine Faculty of Health Sciences University of Cape Town |
| spellingShingle | Medicine Palkowski, Gregori H Cardiovascular magnetic resonance characterisation of myocardial involvement in tuberculous pericardial constriction with and without HIV co-infection |
| thesis_degree_str | Master's |
| title | Cardiovascular magnetic resonance characterisation of myocardial involvement in tuberculous pericardial constriction with and without HIV co-infection |
| title_full | Cardiovascular magnetic resonance characterisation of myocardial involvement in tuberculous pericardial constriction with and without HIV co-infection |
| title_fullStr | Cardiovascular magnetic resonance characterisation of myocardial involvement in tuberculous pericardial constriction with and without HIV co-infection |
| title_full_unstemmed | Cardiovascular magnetic resonance characterisation of myocardial involvement in tuberculous pericardial constriction with and without HIV co-infection |
| title_short | Cardiovascular magnetic resonance characterisation of myocardial involvement in tuberculous pericardial constriction with and without HIV co-infection |
| title_sort | cardiovascular magnetic resonance characterisation of myocardial involvement in tuberculous pericardial constriction with and without hiv co infection |
| topic | Medicine |
| url | http://hdl.handle.net/11427/23659 |
| work_keys_str_mv | AT palkowskigregorih cardiovascularmagneticresonancecharacterisationofmyocardialinvolvementintuberculouspericardialconstrictionwithandwithouthivcoinfection |