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The aetiology and pathogenesis of tropical ulcer
Tropical ulcer is a very specific form of cutaneous ulceration. It occurs worldwide in most tropical and a number of subtropical areas. The disease occurs mainly in older children and young adults with children under the age of 5 and adults over 45 years rarely being affected. Ulcers occur most comm...
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| Format: | Thesis |
| Language: | English |
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Division of Dermatology
2017
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| _version_ | 1867613305780043777 |
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| access_status_str | Open Access |
| author | Adriaans, Beverley |
| author2 | Hay, roderick J |
| author_browse | Adriaans, Beverley Hay, roderick J |
| author_facet | Hay, roderick J Adriaans, Beverley |
| author_sort | Adriaans, Beverley |
| collection | Thesis |
| description | Tropical ulcer is a very specific form of cutaneous ulceration. It occurs worldwide in most tropical and a number of subtropical areas. The disease occurs mainly in older children and young adults with children under the age of 5 and adults over 45 years rarely being affected. Ulcers occur most commonly on the lower leg but may occur on the upper limb. Although most ulcers normally heal slowly over many weeks or months, some ulcers may recur. Recognised complications include squamous cell carcinoma, gangrene and osteitis, although these are rare. A number of authors have reported on the disease and suggested diet, trauma and infection as aetiological factors for this condition. This survey was thus conducted to assess as many of these factors as possible. The study took place in 5 tropical areas, namely Zambia, Gambia, southern India, Fiji and Papua New Guinea. Consultations took place at hospitals, rural clinics, health centres and villages. Although many authors have suggested that the disease is related to malnutrition, few have objectively assessed the nutritional status of the patients and compared it with controls. Those studies which included objective assessments were limited to small areas and only investigated specific parameters. In order to investigate the immune response of the host to an anaerobic infection, the antibody levels to the organisms isolated from the ulcers were measured by an ELISA test. The local host response to an infection with a Fusobacterium species was assessed by the number of antibody secreting B-lymphocytes at the site of the ulcers. These parameters may play a role in the localisation of the ulcers and account for recurrent infections. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/25758 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:34:00.978Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2017 |
| publishDateRange | 2017 |
| publishDateSort | 2017 |
| publisher | Division of Dermatology |
| publisherStr | Division of Dermatology |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/25758 The aetiology and pathogenesis of tropical ulcer Adriaans, Beverley Hay, roderick J Drasar, Bohumil S Leg ulcer - Aetiology Skin ulcer - Aetiology Leg - Ulcers - Etiology Skin - Ulcers - Etiology Tropical ulcer is a very specific form of cutaneous ulceration. It occurs worldwide in most tropical and a number of subtropical areas. The disease occurs mainly in older children and young adults with children under the age of 5 and adults over 45 years rarely being affected. Ulcers occur most commonly on the lower leg but may occur on the upper limb. Although most ulcers normally heal slowly over many weeks or months, some ulcers may recur. Recognised complications include squamous cell carcinoma, gangrene and osteitis, although these are rare. A number of authors have reported on the disease and suggested diet, trauma and infection as aetiological factors for this condition. This survey was thus conducted to assess as many of these factors as possible. The study took place in 5 tropical areas, namely Zambia, Gambia, southern India, Fiji and Papua New Guinea. Consultations took place at hospitals, rural clinics, health centres and villages. Although many authors have suggested that the disease is related to malnutrition, few have objectively assessed the nutritional status of the patients and compared it with controls. Those studies which included objective assessments were limited to small areas and only investigated specific parameters. In order to investigate the immune response of the host to an anaerobic infection, the antibody levels to the organisms isolated from the ulcers were measured by an ELISA test. The local host response to an infection with a Fusobacterium species was assessed by the number of antibody secreting B-lymphocytes at the site of the ulcers. These parameters may play a role in the localisation of the ulcers and account for recurrent infections. 2017-10-25T07:48:46Z 2017-10-25T07:48:46Z 1988 2017-07-21T09:09:33Z Master Thesis Masters MD http://hdl.handle.net/11427/25758 eng application/pdf Division of Dermatology Faculty of Health Sciences University of Cape Town |
| spellingShingle | Leg ulcer - Aetiology Skin ulcer - Aetiology Leg - Ulcers - Etiology Skin - Ulcers - Etiology Adriaans, Beverley The aetiology and pathogenesis of tropical ulcer |
| thesis_degree_str | Master's |
| title | The aetiology and pathogenesis of tropical ulcer |
| title_full | The aetiology and pathogenesis of tropical ulcer |
| title_fullStr | The aetiology and pathogenesis of tropical ulcer |
| title_full_unstemmed | The aetiology and pathogenesis of tropical ulcer |
| title_short | The aetiology and pathogenesis of tropical ulcer |
| title_sort | aetiology and pathogenesis of tropical ulcer |
| topic | Leg ulcer - Aetiology Skin ulcer - Aetiology Leg - Ulcers - Etiology Skin - Ulcers - Etiology |
| url | http://hdl.handle.net/11427/25758 |
| work_keys_str_mv | AT adriaansbeverley theaetiologyandpathogenesisoftropicalulcer AT adriaansbeverley aetiologyandpathogenesisoftropicalulcer |