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The development of a system of 24 hours preservation of the heart for transplantation
This thesis describes a series of investigations into the problems that hamper the progress of myocardial preservation for transplantation in man. Six positive aspects of cardiac preservation have emerged from this study: - (1) A clear fluid hyperosmolar solution was formulated that adequately prese...
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| Format: | Thesis |
| Language: | English |
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Division of Cardiology
2017
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| _version_ | 1867614446423113728 |
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| access_status_str | Open Access |
| author | Wicomb, Winston Neville |
| author2 | Barnard, Christiaan Neethling |
| author_browse | Barnard, Christiaan Neethling Wicomb, Winston Neville |
| author_facet | Barnard, Christiaan Neethling Wicomb, Winston Neville |
| author_sort | Wicomb, Winston Neville |
| collection | Thesis |
| description | This thesis describes a series of investigations into the problems that hamper the progress of myocardial preservation for transplantation in man. Six positive aspects of cardiac preservation have emerged from this study: - (1) A clear fluid hyperosmolar solution was formulated that adequately preserved viability of pig and baboon hearts. (2) A pneumatically powered portable preservation unit was designed which successfully preserved pig and baboon hearts when assessed by either functional testing or orthotopic transplantation. (3) A method of in vitro testing of hearts was developed that correlated with results from orthotopic transplantation. (4) A technique of cardiac autotransplantation in baboons was perfected. (5) The high release of lysosomal acid phosphatase during the period of hypothermic preservation was shown to be non-pathological and was reversible after a period of warm blood perfusion. (6) Successful preservation of human hearts for periods longer than 4 hours, not previously achieved, was obtained. The preservation solution and the portable preservation unit that emerged from this experimental study were thoroughly investigated before clinical application. During the development of this perfusate the author had numerous consultations and discussions with colleagues and senior members of neighbouring departments. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/25853 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:52:10.503Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2017 |
| publishDateRange | 2017 |
| publishDateSort | 2017 |
| publisher | Division of Cardiology |
| publisherStr | Division of Cardiology |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/25853 The development of a system of 24 hours preservation of the heart for transplantation Wicomb, Winston Neville Barnard, Christiaan Neethling Organ Preservation - methods Heart This thesis describes a series of investigations into the problems that hamper the progress of myocardial preservation for transplantation in man. Six positive aspects of cardiac preservation have emerged from this study: - (1) A clear fluid hyperosmolar solution was formulated that adequately preserved viability of pig and baboon hearts. (2) A pneumatically powered portable preservation unit was designed which successfully preserved pig and baboon hearts when assessed by either functional testing or orthotopic transplantation. (3) A method of in vitro testing of hearts was developed that correlated with results from orthotopic transplantation. (4) A technique of cardiac autotransplantation in baboons was perfected. (5) The high release of lysosomal acid phosphatase during the period of hypothermic preservation was shown to be non-pathological and was reversible after a period of warm blood perfusion. (6) Successful preservation of human hearts for periods longer than 4 hours, not previously achieved, was obtained. The preservation solution and the portable preservation unit that emerged from this experimental study were thoroughly investigated before clinical application. During the development of this perfusate the author had numerous consultations and discussions with colleagues and senior members of neighbouring departments. 2017-10-27T06:53:32Z 2017-10-27T06:53:32Z 1983 2017-04-24T14:10:42Z Doctoral Thesis Doctoral PhD http://hdl.handle.net/11427/25853 eng application/pdf Division of Cardiology Faculty of Health Sciences University of Cape Town |
| spellingShingle | Organ Preservation - methods Heart Wicomb, Winston Neville The development of a system of 24 hours preservation of the heart for transplantation |
| thesis_degree_str | Doctoral |
| title | The development of a system of 24 hours preservation of the heart for transplantation |
| title_full | The development of a system of 24 hours preservation of the heart for transplantation |
| title_fullStr | The development of a system of 24 hours preservation of the heart for transplantation |
| title_full_unstemmed | The development of a system of 24 hours preservation of the heart for transplantation |
| title_short | The development of a system of 24 hours preservation of the heart for transplantation |
| title_sort | development of a system of 24 hours preservation of the heart for transplantation |
| topic | Organ Preservation - methods Heart |
| url | http://hdl.handle.net/11427/25853 |
| work_keys_str_mv | AT wicombwinstonneville thedevelopmentofasystemof24hourspreservationoftheheartfortransplantation AT wicombwinstonneville developmentofasystemof24hourspreservationoftheheartfortransplantation |