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The prognosis of tuberculosis in adults infected with Human Immunodeficiency Virus (HIV-1)
Objectives: The primary objective of this study was to assess whether active tuberculosis (TB) accelerates the course of HIV-1 infection by measuring progression to AIDS and mortality in HIV-infected patients. Secondary objectives were to evaluate whether TB should be considered an AIDS-defining ill...
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| Format: | Thesis |
| Language: | English |
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Department of Public Health and Family Medicine
2017
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| _version_ | 1867613233999773697 |
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| access_status_str | Open Access |
| author | Badri, Motasim Hassan Yousof |
| author2 | Maartens, Gary |
| author_browse | Badri, Motasim Hassan Yousof Maartens, Gary |
| author_facet | Maartens, Gary Badri, Motasim Hassan Yousof |
| author_sort | Badri, Motasim Hassan Yousof |
| collection | Thesis |
| description | Objectives: The primary objective of this study was to assess whether active tuberculosis (TB) accelerates the course of HIV-1 infection by measuring progression to AIDS and mortality in HIV-infected patients. Secondary objectives were to evaluate whether TB should be considered an AIDS-defining illness in an area with a high prevalence of TB, and to assess the risk factors for developing TB in HIV-1 infected patients. Setting: New Somerset and Groote Schuur Hospital adult HIV clinics, Department of Medicine, Faculty of Health Sciences, University of Cape Town. Design: Prospective patient cohort study with five years of follow-up. Sample: Adult HIV-infected patients presenting to the two HIV clinics between 1992 and 1996. Methods: The TB case definition was a positive culture or a compatible clinical picture combined with a positive smear or a histologic diagnosis. TB patients were treated with 6-month short course regimens. The Kaplan-Meier method was used to estimate the overall survival times of tuberculosis and non-tuberculosis patients. The generalized log rank test was used to compare the survival curves of these two groups. The Cox proportional hazards regression method was used to determine the risk of death associated with tuberculosis while adjusting for potential confounding variables (i.e. age, CD4+ count, history of an AIDS-defining illness, use of co-trimoxazole prophylaxis, and antiretroviral therapy, etc.). The Kaplan-Meier method was used to evaluate the prognosis of HIV-infected patients with TB vs the prognosis of HIV-infected with other HIV ( or AIDS, as defined by the WHO or the CDC staging systems) related diseases at baseline. The generalized log rank test was used to compare the survival curves of the TB group vs the other groups. Predictors of active TB in HIV-infected patients were assessed using univariate and multivariate logistic regression models. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/26340 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:32:52.713Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2017 |
| publishDateRange | 2017 |
| publishDateSort | 2017 |
| publisher | Department of Public Health and Family Medicine |
| publisherStr | Department of Public Health and Family Medicine |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/26340 The prognosis of tuberculosis in adults infected with Human Immunodeficiency Virus (HIV-1) Badri, Motasim Hassan Yousof Maartens, Gary Ehrlich, Rodney Community Health Objectives: The primary objective of this study was to assess whether active tuberculosis (TB) accelerates the course of HIV-1 infection by measuring progression to AIDS and mortality in HIV-infected patients. Secondary objectives were to evaluate whether TB should be considered an AIDS-defining illness in an area with a high prevalence of TB, and to assess the risk factors for developing TB in HIV-1 infected patients. Setting: New Somerset and Groote Schuur Hospital adult HIV clinics, Department of Medicine, Faculty of Health Sciences, University of Cape Town. Design: Prospective patient cohort study with five years of follow-up. Sample: Adult HIV-infected patients presenting to the two HIV clinics between 1992 and 1996. Methods: The TB case definition was a positive culture or a compatible clinical picture combined with a positive smear or a histologic diagnosis. TB patients were treated with 6-month short course regimens. The Kaplan-Meier method was used to estimate the overall survival times of tuberculosis and non-tuberculosis patients. The generalized log rank test was used to compare the survival curves of these two groups. The Cox proportional hazards regression method was used to determine the risk of death associated with tuberculosis while adjusting for potential confounding variables (i.e. age, CD4+ count, history of an AIDS-defining illness, use of co-trimoxazole prophylaxis, and antiretroviral therapy, etc.). The Kaplan-Meier method was used to evaluate the prognosis of HIV-infected patients with TB vs the prognosis of HIV-infected with other HIV ( or AIDS, as defined by the WHO or the CDC staging systems) related diseases at baseline. The generalized log rank test was used to compare the survival curves of the TB group vs the other groups. Predictors of active TB in HIV-infected patients were assessed using univariate and multivariate logistic regression models. 2017-11-16T14:03:01Z 2017-11-16T14:03:01Z 1999 2017-04-19T14:15:18Z Master Thesis Masters MMed http://hdl.handle.net/11427/26340 eng application/pdf Department of Public Health and Family Medicine Faculty of Health Sciences University of Cape Town |
| spellingShingle | Community Health Badri, Motasim Hassan Yousof The prognosis of tuberculosis in adults infected with Human Immunodeficiency Virus (HIV-1) |
| thesis_degree_str | Master's |
| title | The prognosis of tuberculosis in adults infected with Human Immunodeficiency Virus (HIV-1) |
| title_full | The prognosis of tuberculosis in adults infected with Human Immunodeficiency Virus (HIV-1) |
| title_fullStr | The prognosis of tuberculosis in adults infected with Human Immunodeficiency Virus (HIV-1) |
| title_full_unstemmed | The prognosis of tuberculosis in adults infected with Human Immunodeficiency Virus (HIV-1) |
| title_short | The prognosis of tuberculosis in adults infected with Human Immunodeficiency Virus (HIV-1) |
| title_sort | prognosis of tuberculosis in adults infected with human immunodeficiency virus hiv 1 |
| topic | Community Health |
| url | http://hdl.handle.net/11427/26340 |
| work_keys_str_mv | AT badrimotasimhassanyousof theprognosisoftuberculosisinadultsinfectedwithhumanimmunodeficiencyvirushiv1 AT badrimotasimhassanyousof prognosisoftuberculosisinadultsinfectedwithhumanimmunodeficiencyvirushiv1 |