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Isoflurane : interaction with hepatic microsomal enzymes

lsoflurane interacts with cytochrome P-450 in rat and human hepatic microsomes and the Δ6- and Δ5-desaturases in rat hepatic microsomes. The interaction of isoflurane with cytochrome P-450 results in its metabolism to fluoride ion and organofluorine metabolites. The cytochrome P-450 isozymes catalys...

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Bibliographic Details
Main Author: Bradshaw, Jennifer Jean
Other Authors: Gevers, Wieland
Format: Thesis
Language:English
Published: Division of Medical Biochemistry and Structural Biology 2018
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