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The innate immune response to Mycobacterium tuberculosis is dependent on strain lineage and on host population
Includes abstract.
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| Main Author: | |
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
| Published: |
Division of Medical Microbiology
2014
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| _version_ | 1867613281339834368 |
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| access_status_str | Open Access |
| author | Sarkar, Rajesh |
| author2 | Nicol, Mark |
| author_browse | Nicol, Mark Sarkar, Rajesh |
| author_facet | Nicol, Mark Sarkar, Rajesh |
| author_sort | Sarkar, Rajesh |
| collection | Thesis |
| description | Includes abstract. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/2719 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:33:37.862Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2014 |
| publishDateRange | 2014 |
| publishDateSort | 2014 |
| publisher | Division of Medical Microbiology |
| publisherStr | Division of Medical Microbiology |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/2719 The innate immune response to Mycobacterium tuberculosis is dependent on strain lineage and on host population Sarkar, Rajesh Nicol, Mark Wilkinson, R J Medical Microbiology Includes abstract. Includes bibliographical references. The genome structure of Mycobacterium tuberculosis is strongly clonal, in the absence of horizontal gene transfer. Thus it is feasible that clonal lineages may exhibit particular phenotypic characteristics, which may, in turn, result in differences in virulence or influence their association with particular host populations. Indeed, the global distribution of M. tuberculosis strains is not uniform and certain strain lineages predominate in particular geographical areas. Further, there is evidence that some strain lineages are emerging, suggesting differences in virulence. Firstly, we investigated the association between strain genotype of M. tuberculosis and in vitro correlates of virulence such as growth phenotype and cytokine induction in the monocyte-derived macrophage (MDM) model. 2014-07-28T08:17:43Z 2014-07-28T08:17:43Z 2013 Doctoral Thesis Doctoral PhD http://hdl.handle.net/11427/2719 eng application/pdf Division of Medical Microbiology Faculty of Health Sciences University of Cape Town |
| spellingShingle | Medical Microbiology Sarkar, Rajesh The innate immune response to Mycobacterium tuberculosis is dependent on strain lineage and on host population |
| thesis_degree_str | Doctoral |
| title | The innate immune response to Mycobacterium tuberculosis is dependent on strain lineage and on host population |
| title_full | The innate immune response to Mycobacterium tuberculosis is dependent on strain lineage and on host population |
| title_fullStr | The innate immune response to Mycobacterium tuberculosis is dependent on strain lineage and on host population |
| title_full_unstemmed | The innate immune response to Mycobacterium tuberculosis is dependent on strain lineage and on host population |
| title_short | The innate immune response to Mycobacterium tuberculosis is dependent on strain lineage and on host population |
| title_sort | innate immune response to mycobacterium tuberculosis is dependent on strain lineage and on host population |
| topic | Medical Microbiology |
| url | http://hdl.handle.net/11427/2719 |
| work_keys_str_mv | AT sarkarrajesh theinnateimmuneresponsetomycobacteriumtuberculosisisdependentonstrainlineageandonhostpopulation AT sarkarrajesh innateimmuneresponsetomycobacteriumtuberculosisisdependentonstrainlineageandonhostpopulation |