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Uric acid metabolism in the Dalmatian coach hound
The Dalmatian coach hound, when compared to other dog breeds, exhibits three characteristic abnormalities of uric acid metabolism, namely hyperuricaemia, hyperuricosuria and increased renal uric acid clearance. These properties are associated with hypoallantoinaemia and hypoallantoinuria. A result...
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| Format: | Thesis |
| Language: | English |
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Division of Chemical Pathology
2018
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| _version_ | 1867613301495562240 |
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| access_status_str | Open Access |
| author | Briggs, Oliver Martin |
| author2 | Harley, Eric H |
| author_browse | Briggs, Oliver Martin Harley, Eric H |
| author_facet | Harley, Eric H Briggs, Oliver Martin |
| author_sort | Briggs, Oliver Martin |
| collection | Thesis |
| description | The Dalmatian coach hound, when compared to other dog breeds, exhibits three characteristic abnormalities of uric acid metabolism, namely hyperuricaemia, hyperuricosuria and increased renal uric acid clearance. These properties are associated with hypoallantoinaemia and hypoallantoinuria. A result of these abnormalities is a high incidence of urate urolithiasis in this breed. Other diseases such as recurrent dermatitis, chronic cystitis and deafness are also found in the Dalmatian and whether there is any causal relationship with the uric acid disorder is unknown. In terms of the quantity of uric acid excreted, the Dalmatian dog resembles man more closely than the non-Dalmatian. On the other hand, in its high renal urate clearance, this breed of dogs differs from man, whose renal clearance values are lower and therefore closer to those of the non-Dalmatian. In this respect the Dalmatian resembles man affected with the inborn renal urate transport defect of renal hypouricaemia. The significance of uric acid metabolism in the Dalmatian has attracted many investigators in search of the underlying metabolic defect(s). Study of the Dalmatian may also be relevant to the understanding of disorders of purine metabolism in man for example hyperuricosuria, uric acid urolithiasis and hereditary renal hypouricaemia. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/27257 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:33:57.504Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2018 |
| publishDateRange | 2018 |
| publishDateSort | 2018 |
| publisher | Division of Chemical Pathology |
| publisherStr | Division of Chemical Pathology |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/27257 Uric acid metabolism in the Dalmatian coach hound Briggs, Oliver Martin Harley, Eric H Chemical Pathology The Dalmatian coach hound, when compared to other dog breeds, exhibits three characteristic abnormalities of uric acid metabolism, namely hyperuricaemia, hyperuricosuria and increased renal uric acid clearance. These properties are associated with hypoallantoinaemia and hypoallantoinuria. A result of these abnormalities is a high incidence of urate urolithiasis in this breed. Other diseases such as recurrent dermatitis, chronic cystitis and deafness are also found in the Dalmatian and whether there is any causal relationship with the uric acid disorder is unknown. In terms of the quantity of uric acid excreted, the Dalmatian dog resembles man more closely than the non-Dalmatian. On the other hand, in its high renal urate clearance, this breed of dogs differs from man, whose renal clearance values are lower and therefore closer to those of the non-Dalmatian. In this respect the Dalmatian resembles man affected with the inborn renal urate transport defect of renal hypouricaemia. The significance of uric acid metabolism in the Dalmatian has attracted many investigators in search of the underlying metabolic defect(s). Study of the Dalmatian may also be relevant to the understanding of disorders of purine metabolism in man for example hyperuricosuria, uric acid urolithiasis and hereditary renal hypouricaemia. 2018-02-05T12:35:47Z 2018-02-05T12:35:47Z 1982 Master Thesis Masters MSc (Med) http://hdl.handle.net/11427/27257 eng application/pdf Division of Chemical Pathology Faculty of Health Sciences University of Cape Town |
| spellingShingle | Chemical Pathology Briggs, Oliver Martin Uric acid metabolism in the Dalmatian coach hound |
| thesis_degree_str | Master's |
| title | Uric acid metabolism in the Dalmatian coach hound |
| title_full | Uric acid metabolism in the Dalmatian coach hound |
| title_fullStr | Uric acid metabolism in the Dalmatian coach hound |
| title_full_unstemmed | Uric acid metabolism in the Dalmatian coach hound |
| title_short | Uric acid metabolism in the Dalmatian coach hound |
| title_sort | uric acid metabolism in the dalmatian coach hound |
| topic | Chemical Pathology |
| url | http://hdl.handle.net/11427/27257 |
| work_keys_str_mv | AT briggsolivermartin uricacidmetabolisminthedalmatiancoachhound |