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Evaluation of the in vivo role of vaccinia virus complement control protein (VCP) following renal ischemia
Includes bibliographical references (leaves 133-147)
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| Main Author: | |
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
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Division of Virology
2014
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| _version_ | 1867613289305866240 |
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| access_status_str | Open Access |
| author | Ghebremariam, Yohannes T |
| author2 | Kotwal, Girish J |
| author_browse | Ghebremariam, Yohannes T Kotwal, Girish J |
| author_facet | Kotwal, Girish J Ghebremariam, Yohannes T |
| author_sort | Ghebremariam, Yohannes T |
| collection | Thesis |
| description | Includes bibliographical references (leaves 133-147) |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/2726 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:33:45.686Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2014 |
| publishDateRange | 2014 |
| publishDateSort | 2014 |
| publisher | Division of Virology |
| publisherStr | Division of Virology |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/2726 Evaluation of the in vivo role of vaccinia virus complement control protein (VCP) following renal ischemia Ghebremariam, Yohannes T Kotwal, Girish J Kahn, Del Medical Virology Includes bibliographical references (leaves 133-147) In transplantation, vascularized organs often suffer the consequences of ischemic damage as well as reperfusion injury following the reestablishment of blood flow. The induced ischemialreperfusion (I/R) damage is usually associated with the accumulation of injurious complement components. The vaccinia virus complement control protein (VCP) has the ability to simultaneously inhibit the classical and the alternative complement pathways by binding to the early components C3b and C4b. The complement component C3 is known to be the central route to all of the known complement activation pathways. As a result, it is involved in a number of complement-mediated ailments including renal ischemia/reperfusion injury. The objectives of this study were to initially evaluate the in vitro roles of the natural VCP and the humanized recombinant VCP (hrVCP), and then to establish their in vivo roles in a renal I/R injury model. 2014-07-28T08:19:13Z 2014-07-28T08:19:13Z 2006 Doctoral Thesis Doctoral PhD http://hdl.handle.net/11427/2726 eng application/pdf Division of Virology Faculty of Health Sciences University of Cape Town |
| spellingShingle | Medical Virology Ghebremariam, Yohannes T Evaluation of the in vivo role of vaccinia virus complement control protein (VCP) following renal ischemia |
| thesis_degree_str | Doctoral |
| title | Evaluation of the in vivo role of vaccinia virus complement control protein (VCP) following renal ischemia |
| title_full | Evaluation of the in vivo role of vaccinia virus complement control protein (VCP) following renal ischemia |
| title_fullStr | Evaluation of the in vivo role of vaccinia virus complement control protein (VCP) following renal ischemia |
| title_full_unstemmed | Evaluation of the in vivo role of vaccinia virus complement control protein (VCP) following renal ischemia |
| title_short | Evaluation of the in vivo role of vaccinia virus complement control protein (VCP) following renal ischemia |
| title_sort | evaluation of the in vivo role of vaccinia virus complement control protein vcp following renal ischemia |
| topic | Medical Virology |
| url | http://hdl.handle.net/11427/2726 |
| work_keys_str_mv | AT ghebremariamyohannest evaluationoftheinvivoroleofvacciniaviruscomplementcontrolproteinvcpfollowingrenalischemia |