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Repositioning fusidic acid for tuberculosis: semi-synthesis of analogues and impact of mycobacterial biotransformation on antibiotic activity

Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), is one of the leading causes of death globally, especially in low and middle-income countries. TB is primarily a curable disease, with chemotherapy predicated on a combination of four drugs. The increase in multiple forms of drug-resista...

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Bibliographic Details
Main Author: Wasuna, Antonina
Other Authors: Chibale, Kelly
Format: Thesis
Language:English
Published: Department of Chemistry 2018
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