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Cognitive outcomes in adults with HIV-associated Tuberculous Meningitis
Tuberculous meningitis (TBM) is a common cause of meningitis in adults in South Africa (1-3), second only to cryptococcal meningitis in studies of microbiologically confirmed meningitis, and accounting for 28% of cases in one (1). Conventional diagnostic tests for TBM are, however, relatively insens...
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| Format: | Thesis |
| Language: | English |
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Department of Medicine
2019
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| _version_ | 1867613330918604800 |
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| access_status_str | Open Access |
| author | Albertyn, Christine Herculine |
| author2 | Solms, Mark |
| author_browse | Albertyn, Christine Herculine Solms, Mark |
| author_facet | Solms, Mark Albertyn, Christine Herculine |
| author_sort | Albertyn, Christine Herculine |
| collection | Thesis |
| description | Tuberculous meningitis (TBM) is a common cause of meningitis in adults in South Africa (1-3), second only to cryptococcal meningitis in studies of microbiologically confirmed meningitis, and accounting for 28% of cases in one (1). Conventional diagnostic tests for TBM are, however, relatively insensitive, and the true incidence is likely to be underreported. When both microbiological and clinical diagnostic criteria (4) are used in the same setting, the incidence of TBM rose to 57% (3), emerging as the most common cause of meningitis in adults in a district level hospital in the Western Cape. In the setting of high human immunodeficiency virus (HIV) and tuberculosis (TB) prevalence, approximately 88% of patients with definite or probable TBM are co-infected with HIV (3, 5) and six-month mortality in this group approaches 50% (3). Survivors may be left with long-term disability secondary to hydrocephalus, cranial neuropathies, seizures and strokes (6). |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/29405 |
| institution | University of Cape Town (South Africa) |
| language | English |
| last_indexed | 2026-06-10T12:34:25.395Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2019 |
| publishDateRange | 2019 |
| publishDateSort | 2019 |
| publisher | Department of Medicine |
| publisherStr | Department of Medicine |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/29405 Cognitive outcomes in adults with HIV-associated Tuberculous Meningitis Albertyn, Christine Herculine Solms, Mark Marais, Suzaan Gouse, Theta Bateman, Kathleen medicine Tuberculous meningitis (TBM) is a common cause of meningitis in adults in South Africa (1-3), second only to cryptococcal meningitis in studies of microbiologically confirmed meningitis, and accounting for 28% of cases in one (1). Conventional diagnostic tests for TBM are, however, relatively insensitive, and the true incidence is likely to be underreported. When both microbiological and clinical diagnostic criteria (4) are used in the same setting, the incidence of TBM rose to 57% (3), emerging as the most common cause of meningitis in adults in a district level hospital in the Western Cape. In the setting of high human immunodeficiency virus (HIV) and tuberculosis (TB) prevalence, approximately 88% of patients with definite or probable TBM are co-infected with HIV (3, 5) and six-month mortality in this group approaches 50% (3). Survivors may be left with long-term disability secondary to hydrocephalus, cranial neuropathies, seizures and strokes (6). 2019-02-07T10:54:28Z 2019-02-07T10:54:28Z 2017 Thesis MSc (Med) http://hdl.handle.net/11427/29405 en application/pdf Department of Medicine Faculty of Health Sciences University of Cape Town |
| spellingShingle | medicine Albertyn, Christine Herculine Cognitive outcomes in adults with HIV-associated Tuberculous Meningitis |
| title | Cognitive outcomes in adults with HIV-associated Tuberculous Meningitis |
| title_full | Cognitive outcomes in adults with HIV-associated Tuberculous Meningitis |
| title_fullStr | Cognitive outcomes in adults with HIV-associated Tuberculous Meningitis |
| title_full_unstemmed | Cognitive outcomes in adults with HIV-associated Tuberculous Meningitis |
| title_short | Cognitive outcomes in adults with HIV-associated Tuberculous Meningitis |
| title_sort | cognitive outcomes in adults with hiv associated tuberculous meningitis |
| topic | medicine |
| url | http://hdl.handle.net/11427/29405 |
| work_keys_str_mv | AT albertynchristineherculine cognitiveoutcomesinadultswithhivassociatedtuberculousmeningitis |