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Evolution of sensory neuropathy after initiation of antiretroviral therapy
Introduction: We studied the evolution of sensory neuropathy after antiretroviral therapy (ART) in human immunodeficiency virus–infected South Africans. Methods: Enrolment commenced before ART with 6-monthly follow-ups for 24 months. Symptomatic distal sensory polyneuropathy (SDSP) was defined as on...
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| Format: | Thesis |
| Language: | English |
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Division of Medical Microbiology
2019
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| _version_ | 1867613281372340224 |
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| access_status_str | Open Access |
| author | Centner, Chad |
| author2 | Heckmann, Jeannine M |
| author_browse | Centner, Chad Heckmann, Jeannine M |
| author_facet | Heckmann, Jeannine M Centner, Chad |
| author_sort | Centner, Chad |
| collection | Thesis |
| description | Introduction: We studied the evolution of sensory neuropathy after antiretroviral therapy (ART) in human immunodeficiency virus–infected South Africans. Methods: Enrolment commenced before ART with 6-monthly follow-ups for 24 months. Symptomatic distal sensory polyneuropathy (SDSP) was defined as one symptom and sign. Symptom/sign scores were compared between visits. Results: We enrolled 184 participants. Pre-ART, 16% had SDSP. After 18 months of ART, pain prevalence decreased in those with pre-ART SDSP (odds ratio [OR], 0.09; 95% confidence interval [95%CI], 0.03-0.29). Symptoms improved in 50% ever experiencing pain (mean improvement=-4.5 on 11-point scale). Participants SDSP-free pre-ART developed SDSP at a rate of 18 per 100 person-years. After 24 months, 18% had SDSP. Stavudine (60% of cohort) did not predict incident SDSP, but associated with increased prevalence of reduced/absent reflexes at 18 months (OR, 2.24; 95% CI, 1.08-4.65). Conclusions: Painful symptoms improved during ART. Evolving sensory neuropathy was due to increasing small and large fiber dysfunction. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/29605 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:33:37.862Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2019 |
| publishDateRange | 2019 |
| publishDateSort | 2019 |
| publisher | Division of Medical Microbiology |
| publisherStr | Division of Medical Microbiology |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/29605 Evolution of sensory neuropathy after initiation of antiretroviral therapy Centner, Chad Heckmann, Jeannine M Medical Microbiology Introduction: We studied the evolution of sensory neuropathy after antiretroviral therapy (ART) in human immunodeficiency virus–infected South Africans. Methods: Enrolment commenced before ART with 6-monthly follow-ups for 24 months. Symptomatic distal sensory polyneuropathy (SDSP) was defined as one symptom and sign. Symptom/sign scores were compared between visits. Results: We enrolled 184 participants. Pre-ART, 16% had SDSP. After 18 months of ART, pain prevalence decreased in those with pre-ART SDSP (odds ratio [OR], 0.09; 95% confidence interval [95%CI], 0.03-0.29). Symptoms improved in 50% ever experiencing pain (mean improvement=-4.5 on 11-point scale). Participants SDSP-free pre-ART developed SDSP at a rate of 18 per 100 person-years. After 24 months, 18% had SDSP. Stavudine (60% of cohort) did not predict incident SDSP, but associated with increased prevalence of reduced/absent reflexes at 18 months (OR, 2.24; 95% CI, 1.08-4.65). Conclusions: Painful symptoms improved during ART. Evolving sensory neuropathy was due to increasing small and large fiber dysfunction. 2019-02-18T10:39:50Z 2019-02-18T10:39:50Z 2018 2019-02-18T08:36:41Z Master Thesis Masters MMed http://hdl.handle.net/11427/29605 eng application/pdf Division of Medical Microbiology Faculty of Health Sciences University of Cape Town |
| spellingShingle | Medical Microbiology Centner, Chad Evolution of sensory neuropathy after initiation of antiretroviral therapy |
| thesis_degree_str | Master's |
| title | Evolution of sensory neuropathy after initiation of antiretroviral therapy |
| title_full | Evolution of sensory neuropathy after initiation of antiretroviral therapy |
| title_fullStr | Evolution of sensory neuropathy after initiation of antiretroviral therapy |
| title_full_unstemmed | Evolution of sensory neuropathy after initiation of antiretroviral therapy |
| title_short | Evolution of sensory neuropathy after initiation of antiretroviral therapy |
| title_sort | evolution of sensory neuropathy after initiation of antiretroviral therapy |
| topic | Medical Microbiology |
| url | http://hdl.handle.net/11427/29605 |
| work_keys_str_mv | AT centnerchad evolutionofsensoryneuropathyafterinitiationofantiretroviraltherapy |