Full Text Available

Access Repository
Note: Clicking the button above will open the full text document at the original institutional repository in a new window.
Cover Image

Colonisation with pathogenic drug-resistant bacteria and Clostridioides difficile among residents of residential care facilities in Cape Town, South Africa

Objectives Residential care facilities (RCFs) act as reservoirs for multidrug-resistant organisms (MDRO). There are scarce data on colonisation with MDROs in Africa. We aimed to determine the prevalence of MDROs and C. difficile and risk factors for carriage amongst residents of RCFs in Cape Town,...

Full description

Saved in:
Main Author: September, Jason
Other Authors: Wasserman, Sean
Format: Thesis
Language:English
Published: Department of Medicine 2020
Subjects:
Medicine
Tags: Add Tag
No Tags, Be the first to tag this record!
_version_ 1867613759878463488
access_status_str Open Access
author September, Jason
author2 Wasserman, Sean
author_browse September, Jason
Wasserman, Sean
author_facet Wasserman, Sean
September, Jason
author_sort September, Jason
collection Thesis
description Objectives Residential care facilities (RCFs) act as reservoirs for multidrug-resistant organisms (MDRO). There are scarce data on colonisation with MDROs in Africa. We aimed to determine the prevalence of MDROs and C. difficile and risk factors for carriage amongst residents of RCFs in Cape Town, South Africa. Methods We performed a cross-sectional surveillance study at three RCFs. Chromogenic agar was used to screen skin swabs for methicillin-resistant Staphylococcus aureus (MRSA) and stool samples for extended-spectrum beta-lactamase-producing Enterobacterales (ESBL-E). Antigen testing and PCR was used to detect Clostridiodes difficile. Risk factors for colonisation were determined with logistic regression. Results One hundred fifty-four residents were enrolled, providing 119 stool samples and 152 sets of skin swabs. Twenty-seven (22.7%) stool samples were positive for ESBL-E, and 13 (8.6%) residents had at least one skin swab positive for MRSA. Two (1.6%) stool samples tested positive for C. difficile. Poor functional status (OR 1.3 (95% CI, 1.0 – 1.6)) and incontinence (OR 2.9 (95% CI, 1.2 – 6.9)) were significant predictors for ESBL-E colonisation. There was a trend towards higher MRSA colonisation in frail care areas. Conclusion There was high prevalence of colonisation with MDROs but low C. difficile carriage, with implications for antibiotic prescribing and infection control practice.
format Thesis
id oai:open.uct.ac.za:11427/31012
institution University of Cape Town (South Africa)
language eng
last_indexed 2026-06-10T12:41:15.763Z
license_str Not specified — see source repository
provenance_str_mv Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository
publishDate 2020
publishDateRange 2020
publishDateSort 2020
publisher Department of Medicine
publisherStr Department of Medicine
record_format dspace
source_str UCTD — University of Cape Town Open Access Repository
spelling oai:open.uct.ac.za:11427/31012 Colonisation with pathogenic drug-resistant bacteria and Clostridioides difficile among residents of residential care facilities in Cape Town, South Africa September, Jason Wasserman, Sean Medicine Objectives Residential care facilities (RCFs) act as reservoirs for multidrug-resistant organisms (MDRO). There are scarce data on colonisation with MDROs in Africa. We aimed to determine the prevalence of MDROs and C. difficile and risk factors for carriage amongst residents of RCFs in Cape Town, South Africa. Methods We performed a cross-sectional surveillance study at three RCFs. Chromogenic agar was used to screen skin swabs for methicillin-resistant Staphylococcus aureus (MRSA) and stool samples for extended-spectrum beta-lactamase-producing Enterobacterales (ESBL-E). Antigen testing and PCR was used to detect Clostridiodes difficile. Risk factors for colonisation were determined with logistic regression. Results One hundred fifty-four residents were enrolled, providing 119 stool samples and 152 sets of skin swabs. Twenty-seven (22.7%) stool samples were positive for ESBL-E, and 13 (8.6%) residents had at least one skin swab positive for MRSA. Two (1.6%) stool samples tested positive for C. difficile. Poor functional status (OR 1.3 (95% CI, 1.0 – 1.6)) and incontinence (OR 2.9 (95% CI, 1.2 – 6.9)) were significant predictors for ESBL-E colonisation. There was a trend towards higher MRSA colonisation in frail care areas. Conclusion There was high prevalence of colonisation with MDROs but low C. difficile carriage, with implications for antibiotic prescribing and infection control practice. 2020-02-11T11:19:01Z 2020-02-11T11:19:01Z 2019 2020-01-28T12:47:12Z Master Thesis Masters MMed http://hdl.handle.net/11427/31012 eng application/pdf Department of Medicine Faculty of Health Sciences
spellingShingle Medicine
September, Jason
Colonisation with pathogenic drug-resistant bacteria and Clostridioides difficile among residents of residential care facilities in Cape Town, South Africa
thesis_degree_str Master's
title Colonisation with pathogenic drug-resistant bacteria and Clostridioides difficile among residents of residential care facilities in Cape Town, South Africa
title_full Colonisation with pathogenic drug-resistant bacteria and Clostridioides difficile among residents of residential care facilities in Cape Town, South Africa
title_fullStr Colonisation with pathogenic drug-resistant bacteria and Clostridioides difficile among residents of residential care facilities in Cape Town, South Africa
title_full_unstemmed Colonisation with pathogenic drug-resistant bacteria and Clostridioides difficile among residents of residential care facilities in Cape Town, South Africa
title_short Colonisation with pathogenic drug-resistant bacteria and Clostridioides difficile among residents of residential care facilities in Cape Town, South Africa
title_sort colonisation with pathogenic drug resistant bacteria and clostridioides difficile among residents of residential care facilities in cape town south africa
topic Medicine
url http://hdl.handle.net/11427/31012
work_keys_str_mv AT septemberjason colonisationwithpathogenicdrugresistantbacteriaandclostridioidesdifficileamongresidentsofresidentialcarefacilitiesincapetownsouthafrica

Similar Items