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The role of IL-4 and IL-13 in pulmonary tuberculosis using gene-deficient mice and protective efficacy of the purine-deficient auxotroph of Mycobacterium tuberculosis
Bibliography: leaves 75-90.
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| Main Author: | |
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
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Division of Immunology
2014
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| _version_ | 1867613240494653440 |
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| access_status_str | Open Access |
| author | Brown, Najmeeyah |
| author2 | Jacobs, Muazzam |
| author_browse | Brown, Najmeeyah Jacobs, Muazzam |
| author_facet | Jacobs, Muazzam Brown, Najmeeyah |
| author_sort | Brown, Najmeeyah |
| collection | Thesis |
| description | Bibliography: leaves 75-90. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/3109 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:32:58.612Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2014 |
| publishDateRange | 2014 |
| publishDateSort | 2014 |
| publisher | Division of Immunology |
| publisherStr | Division of Immunology |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/3109 The role of IL-4 and IL-13 in pulmonary tuberculosis using gene-deficient mice and protective efficacy of the purine-deficient auxotroph of Mycobacterium tuberculosis Brown, Najmeeyah Jacobs, Muazzam Immunology Bibliography: leaves 75-90. Absence of the TH2 inducing cytokine IL-4 has been shown not to increase the TH1 response and resistance to mycobacterial infection. This study asked whether the combined absence of IL-4 and IL3, as compared to IL-4 deficiency only, would increase resistance to an aerogenic Mycobacterium tuberculosis infection. By using IL-4 gene-deficient mice, it was confirmed that endogenous IL-4 does not reduce host immunity. In contrast, IL-4Rα genedeficient mice, which lack both IL-4 and IL-13 signalling, had reduced bacterial burden in the lungs and other organs, increased survival and cellular immunity with macrophage activation. Therefore IL-4Rα gene-deficient mice have increased resistance to Mycobacterium tuberculosis infection. 2014-07-28T14:53:55Z 2014-07-28T14:53:55Z 2002 Doctoral Thesis Doctoral PhD http://hdl.handle.net/11427/3109 eng application/pdf Division of Immunology Faculty of Health Sciences University of Cape Town |
| spellingShingle | Immunology Brown, Najmeeyah The role of IL-4 and IL-13 in pulmonary tuberculosis using gene-deficient mice and protective efficacy of the purine-deficient auxotroph of Mycobacterium tuberculosis |
| thesis_degree_str | Doctoral |
| title | The role of IL-4 and IL-13 in pulmonary tuberculosis using gene-deficient mice and protective efficacy of the purine-deficient auxotroph of Mycobacterium tuberculosis |
| title_full | The role of IL-4 and IL-13 in pulmonary tuberculosis using gene-deficient mice and protective efficacy of the purine-deficient auxotroph of Mycobacterium tuberculosis |
| title_fullStr | The role of IL-4 and IL-13 in pulmonary tuberculosis using gene-deficient mice and protective efficacy of the purine-deficient auxotroph of Mycobacterium tuberculosis |
| title_full_unstemmed | The role of IL-4 and IL-13 in pulmonary tuberculosis using gene-deficient mice and protective efficacy of the purine-deficient auxotroph of Mycobacterium tuberculosis |
| title_short | The role of IL-4 and IL-13 in pulmonary tuberculosis using gene-deficient mice and protective efficacy of the purine-deficient auxotroph of Mycobacterium tuberculosis |
| title_sort | role of il 4 and il 13 in pulmonary tuberculosis using gene deficient mice and protective efficacy of the purine deficient auxotroph of mycobacterium tuberculosis |
| topic | Immunology |
| url | http://hdl.handle.net/11427/3109 |
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