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Prevalence of dyslipidaemia among adults in Africa: a systematic review and meta-analysis
Background The burden of dyslipidaemia in Africa remains inadequately characterised. We aimed to estimate the prevalence of dyslipidaemia in African adults from hospital-based and community-based studies. Methods In this systematic review and meta-analysis, we searched MEDLINE via PubMed...
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| Format: | Thesis |
| Language: | English |
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Department of Medicine
2020
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| _version_ | 1867613939425083392 |
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| access_status_str | Open Access |
| author | Nzeale, Jean Jacques Noubiap |
| author2 | Kengne, Andre Pascal |
| author_browse | Kengne, Andre Pascal Nzeale, Jean Jacques Noubiap |
| author_facet | Kengne, Andre Pascal Nzeale, Jean Jacques Noubiap |
| author_sort | Nzeale, Jean Jacques Noubiap |
| collection | Thesis |
| description | Background
The burden of dyslipidaemia in Africa remains inadequately characterised. We aimed to estimate the prevalence of dyslipidaemia in African adults from hospital-based and community-based studies.
Methods
In this systematic review and meta-analysis, we searched MEDLINE via PubMed, EMBASE, African Journals Online, and African Index Medicus for studies published between Jan 1, 1980, and July 31, 2017, without language restriction. We assessed methodological quality of all crosssectional studies reporting on the prevalence of elevated concentrations of total cholesterol, LDL cholesterol, or triglycerides, or low concentrations of HDL cholesterol in adults residing in African countries. We excluded reports on Africans living outside Africa, studies of individuals selected on the basis of existing dyslipidaemia or those including children and adolescents, and case series with a small sample size. The most frequently used cutoffs in the included studies were chosen for the subgroup analysis. We used random-effect model meta-analysis to derive the pooled prevalence of elevated total cholesterol, low HDL cholesterol, elevated LDL cholesterol, and elevated triglyceride concentrations. This study is registered with PROSPERO, number CRD42014015376.
Findings
177 studies (294063 participants) were included in the meta-analysis. The pooled prevalence of dyslipidaemia in the general population from population-based studies was 25·5% (95% CI 20·0– 31·4) for elevated concentrations of total cholesterol with a cutoff of at least 5·2 mmol/L, 37·4% (29·4–45·7) for low concentrations of HDL cholesterol with a cutoff of less than 1·0 mmol/L, 28·6% (15·8–43·5) for elevated concentrations of LDL cholesterol with a cutoff of at least 3·3 mmol/L, and 17·0% (11·9–22·7) for elevated concentrations of triglycerides with a cutoff of at least 1·7 mmol/L.
Interpretation
The prevalence of dyslipidaemia is high in the general adult population in Africa. Ongoing efforts to reduce cardiovascular diseases in Africa should integrate effective detection and treatment of dyslipidaemia. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/31183 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:44:06.992Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2020 |
| publishDateRange | 2020 |
| publishDateSort | 2020 |
| publisher | Department of Medicine |
| publisherStr | Department of Medicine |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/31183 Prevalence of dyslipidaemia among adults in Africa: a systematic review and meta-analysis Nzeale, Jean Jacques Noubiap Kengne, Andre Pascal Internal Medicine Background The burden of dyslipidaemia in Africa remains inadequately characterised. We aimed to estimate the prevalence of dyslipidaemia in African adults from hospital-based and community-based studies. Methods In this systematic review and meta-analysis, we searched MEDLINE via PubMed, EMBASE, African Journals Online, and African Index Medicus for studies published between Jan 1, 1980, and July 31, 2017, without language restriction. We assessed methodological quality of all crosssectional studies reporting on the prevalence of elevated concentrations of total cholesterol, LDL cholesterol, or triglycerides, or low concentrations of HDL cholesterol in adults residing in African countries. We excluded reports on Africans living outside Africa, studies of individuals selected on the basis of existing dyslipidaemia or those including children and adolescents, and case series with a small sample size. The most frequently used cutoffs in the included studies were chosen for the subgroup analysis. We used random-effect model meta-analysis to derive the pooled prevalence of elevated total cholesterol, low HDL cholesterol, elevated LDL cholesterol, and elevated triglyceride concentrations. This study is registered with PROSPERO, number CRD42014015376. Findings 177 studies (294063 participants) were included in the meta-analysis. The pooled prevalence of dyslipidaemia in the general population from population-based studies was 25·5% (95% CI 20·0– 31·4) for elevated concentrations of total cholesterol with a cutoff of at least 5·2 mmol/L, 37·4% (29·4–45·7) for low concentrations of HDL cholesterol with a cutoff of less than 1·0 mmol/L, 28·6% (15·8–43·5) for elevated concentrations of LDL cholesterol with a cutoff of at least 3·3 mmol/L, and 17·0% (11·9–22·7) for elevated concentrations of triglycerides with a cutoff of at least 1·7 mmol/L. Interpretation The prevalence of dyslipidaemia is high in the general adult population in Africa. Ongoing efforts to reduce cardiovascular diseases in Africa should integrate effective detection and treatment of dyslipidaemia. 2020-02-20T09:38:01Z 2020-02-20T09:38:01Z 2019 2020-02-14T08:10:10Z Master Thesis Masters MMed http://hdl.handle.net/11427/31183 eng application/pdf Department of Medicine Faculty of Health Sciences |
| spellingShingle | Internal Medicine Nzeale, Jean Jacques Noubiap Prevalence of dyslipidaemia among adults in Africa: a systematic review and meta-analysis |
| thesis_degree_str | Master's |
| title | Prevalence of dyslipidaemia among adults in Africa: a systematic review and meta-analysis |
| title_full | Prevalence of dyslipidaemia among adults in Africa: a systematic review and meta-analysis |
| title_fullStr | Prevalence of dyslipidaemia among adults in Africa: a systematic review and meta-analysis |
| title_full_unstemmed | Prevalence of dyslipidaemia among adults in Africa: a systematic review and meta-analysis |
| title_short | Prevalence of dyslipidaemia among adults in Africa: a systematic review and meta-analysis |
| title_sort | prevalence of dyslipidaemia among adults in africa a systematic review and meta analysis |
| topic | Internal Medicine |
| url | http://hdl.handle.net/11427/31183 |
| work_keys_str_mv | AT nzealejeanjacquesnoubiap prevalenceofdyslipidaemiaamongadultsinafricaasystematicreviewandmetaanalysis |