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Expression and functional role of cyclooxygenase enzymes in cervical carcinoma
Bibliography: leaves 133-156.
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
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Division of Medical Biochemistry
2014
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| _version_ | 1867613349493080064 |
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| access_status_str | Open Access |
| author | Sales, Kurt Jason |
| author2 | Katz, Arieh |
| author_browse | Katz, Arieh Sales, Kurt Jason |
| author_facet | Katz, Arieh Sales, Kurt Jason |
| author_sort | Sales, Kurt Jason |
| collection | Thesis |
| description | Bibliography: leaves 133-156. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/3149 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:34:44.389Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2014 |
| publishDateRange | 2014 |
| publishDateSort | 2014 |
| publisher | Division of Medical Biochemistry |
| publisherStr | Division of Medical Biochemistry |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/3149 Expression and functional role of cyclooxygenase enzymes in cervical carcinoma Sales, Kurt Jason Katz, Arieh Jabbour, Henry Medical Biochemistry Bibliography: leaves 133-156. Cervical cancer is considered an important clinical problem in sub-Saharan Africa. Recent studies have suggested that epithelial tumors may be regulated by cyclooxygenase enzyme products. The purpose of this thesis was to determine the expression, localisation and possible functional role of cyclooxygenase enzymes in cervical carcinomas. The initial aim of the study was to determine whether cyclooxygenase-1 and cyclooxygenase-2 expession and prostglandin E₂ synthesis are up-regulated in cervical cancers. Real-time quantitative reverse-transcriptase polymerase chain reaction and Western blot analysis confirmed cyclooxygenase-1 and cyclooxygenase-2 ribonucleic acid and protein expression in all cases of squamous cell carcinoma and adenocarcinoma investigated. In contrast, minimal expression of cyclooxygenase-1 or cyclooxygenase-2 was detected in histologically normal cervix. Immunohistochemical analyses localised the site of cyclooxygenase-1 and cyclooxygenase-2 expression and prostaglandin E₂ synthesis to neoplastic epithelial cells of all squamous cell carcinomas and adenocarcinomas studied. 2014-07-28T14:55:58Z 2014-07-28T14:55:58Z 2001 Doctoral Thesis Doctoral PhD http://hdl.handle.net/11427/3149 eng application/pdf Division of Medical Biochemistry Faculty of Health Sciences University of Cape Town |
| spellingShingle | Medical Biochemistry Sales, Kurt Jason Expression and functional role of cyclooxygenase enzymes in cervical carcinoma |
| thesis_degree_str | Doctoral |
| title | Expression and functional role of cyclooxygenase enzymes in cervical carcinoma |
| title_full | Expression and functional role of cyclooxygenase enzymes in cervical carcinoma |
| title_fullStr | Expression and functional role of cyclooxygenase enzymes in cervical carcinoma |
| title_full_unstemmed | Expression and functional role of cyclooxygenase enzymes in cervical carcinoma |
| title_short | Expression and functional role of cyclooxygenase enzymes in cervical carcinoma |
| title_sort | expression and functional role of cyclooxygenase enzymes in cervical carcinoma |
| topic | Medical Biochemistry |
| url | http://hdl.handle.net/11427/3149 |
| work_keys_str_mv | AT saleskurtjason expressionandfunctionalroleofcyclooxygenaseenzymesincervicalcarcinoma |