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Prevalence of asymptomatic sexually transmitted infections: a retrospective review of screening data from Desmond Tutu HIV Centre clinical trial cohorts from 2012 to 2017, Cape Town
Background: The burden of Sexually transmitted infections (STIs) is high globally. The World Health Organisation (WHO) recommends syndromic management of these STIs, based on presentation with signs and symptoms, in resource-limited countries. Due to this syndromic approach, there is little current...
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| Format: | Thesis |
| Language: | English |
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Department of Public Health and Family Medicine
2020
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| _version_ | 1867613197115064320 |
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| access_status_str | Open Access |
| author | Garnett, Nomcebo Precious |
| author2 | Orrell, Catherine |
| author_browse | Garnett, Nomcebo Precious Orrell, Catherine |
| author_facet | Orrell, Catherine Garnett, Nomcebo Precious |
| author_sort | Garnett, Nomcebo Precious |
| collection | Thesis |
| description | Background: The burden of Sexually transmitted infections (STIs) is high globally. The World Health Organisation (WHO) recommends syndromic management of these STIs, based on presentation with signs and symptoms, in resource-limited countries. Due to this syndromic approach, there is little current data on STI prevalence, including asymptomatic STIs, in high risk populations. Methods: We reviewed secondary data collected as part of the screening procedures of 6 clinical trials between 2012 and 2017 in Cape Town, South Africa. These trials recruited populations of different sexual orientation and gender, mostly key populations at risk of HIV and STI acquisition. Routine screening for STI symptoms and testing for Chlamydia, Gonorrhoea, Trichomonas, Syphilis and HIV was performed for all of the studies at screening/enrollment. Results: A total of 639 participants were screened; 411 (64.3%) self-identifying as female, 198 (31%) males, 29 (4.5%) transgender women and 01 (0.2%) transvestite. Median age was 20 years (IQR: 18-24), with the 15-24-year age category contributing 77% to the cohort. Laboratory testing diagnosed 239 (37.4%) people with STI infections in this cohort; only 28 (11.7%) people were symptomatic. 119 (88.8%) of Chlamydial, 64 (82.1%) of Gonorrhoeal, 23 (92%) of Trichomonal and 31(79.5%) of Syphilis infections elicited no signs and/or symptoms. Conclusion: A vast majority of STIs in this high-risk population were asymptomatic. Laboratory testing of causal organism was more reliable in diagnosing STIs than the use of signs and/or symptoms as recommended by WHO. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/31649 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:32:18.917Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2020 |
| publishDateRange | 2020 |
| publishDateSort | 2020 |
| publisher | Department of Public Health and Family Medicine |
| publisherStr | Department of Public Health and Family Medicine |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/31649 Prevalence of asymptomatic sexually transmitted infections: a retrospective review of screening data from Desmond Tutu HIV Centre clinical trial cohorts from 2012 to 2017, Cape Town Garnett, Nomcebo Precious Orrell, Catherine Sexually transmitted Infection ‘Prevalence Asymptomatic STIs syndromic management of STIs STI testing Background: The burden of Sexually transmitted infections (STIs) is high globally. The World Health Organisation (WHO) recommends syndromic management of these STIs, based on presentation with signs and symptoms, in resource-limited countries. Due to this syndromic approach, there is little current data on STI prevalence, including asymptomatic STIs, in high risk populations. Methods: We reviewed secondary data collected as part of the screening procedures of 6 clinical trials between 2012 and 2017 in Cape Town, South Africa. These trials recruited populations of different sexual orientation and gender, mostly key populations at risk of HIV and STI acquisition. Routine screening for STI symptoms and testing for Chlamydia, Gonorrhoea, Trichomonas, Syphilis and HIV was performed for all of the studies at screening/enrollment. Results: A total of 639 participants were screened; 411 (64.3%) self-identifying as female, 198 (31%) males, 29 (4.5%) transgender women and 01 (0.2%) transvestite. Median age was 20 years (IQR: 18-24), with the 15-24-year age category contributing 77% to the cohort. Laboratory testing diagnosed 239 (37.4%) people with STI infections in this cohort; only 28 (11.7%) people were symptomatic. 119 (88.8%) of Chlamydial, 64 (82.1%) of Gonorrhoeal, 23 (92%) of Trichomonal and 31(79.5%) of Syphilis infections elicited no signs and/or symptoms. Conclusion: A vast majority of STIs in this high-risk population were asymptomatic. Laboratory testing of causal organism was more reliable in diagnosing STIs than the use of signs and/or symptoms as recommended by WHO. 2020-04-21T13:31:41Z 2020-04-21T13:31:41Z 2019 2020-04-21T13:31:24Z Master Thesis Masters MPH https://hdl.handle.net/11427/31649 eng application/pdf Department of Public Health and Family Medicine Faculty of Health Sciences |
| spellingShingle | Sexually transmitted Infection ‘Prevalence Asymptomatic STIs syndromic management of STIs STI testing Garnett, Nomcebo Precious Prevalence of asymptomatic sexually transmitted infections: a retrospective review of screening data from Desmond Tutu HIV Centre clinical trial cohorts from 2012 to 2017, Cape Town |
| thesis_degree_str | Master's |
| title | Prevalence of asymptomatic sexually transmitted infections: a retrospective review of screening data from Desmond Tutu HIV Centre clinical trial cohorts from 2012 to 2017, Cape Town |
| title_full | Prevalence of asymptomatic sexually transmitted infections: a retrospective review of screening data from Desmond Tutu HIV Centre clinical trial cohorts from 2012 to 2017, Cape Town |
| title_fullStr | Prevalence of asymptomatic sexually transmitted infections: a retrospective review of screening data from Desmond Tutu HIV Centre clinical trial cohorts from 2012 to 2017, Cape Town |
| title_full_unstemmed | Prevalence of asymptomatic sexually transmitted infections: a retrospective review of screening data from Desmond Tutu HIV Centre clinical trial cohorts from 2012 to 2017, Cape Town |
| title_short | Prevalence of asymptomatic sexually transmitted infections: a retrospective review of screening data from Desmond Tutu HIV Centre clinical trial cohorts from 2012 to 2017, Cape Town |
| title_sort | prevalence of asymptomatic sexually transmitted infections a retrospective review of screening data from desmond tutu hiv centre clinical trial cohorts from 2012 to 2017 cape town |
| topic | Sexually transmitted Infection ‘Prevalence Asymptomatic STIs syndromic management of STIs STI testing |
| url | https://hdl.handle.net/11427/31649 |
| work_keys_str_mv | AT garnettnomceboprecious prevalenceofasymptomaticsexuallytransmittedinfectionsaretrospectivereviewofscreeningdatafromdesmondtutuhivcentreclinicaltrialcohortsfrom2012to2017capetown |