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Sequence analysis of the E-cadherin (CDH1) gene in a cohort of gastric cancers seen in the Western Cape
Includes abstract.
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
| Published: |
Department of Clinical Laboratory Sciences
2014
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| _version_ | 1867613204823146496 |
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| access_status_str | Open Access |
| author | Jaca, Anelisa |
| author2 | Naidoo, Richard |
| author_browse | Jaca, Anelisa Naidoo, Richard |
| author_facet | Naidoo, Richard Jaca, Anelisa |
| author_sort | Jaca, Anelisa |
| collection | Thesis |
| description | Includes abstract. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/3165 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:32:26.116Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2014 |
| publishDateRange | 2014 |
| publishDateSort | 2014 |
| publisher | Department of Clinical Laboratory Sciences |
| publisherStr | Department of Clinical Laboratory Sciences |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/3165 Sequence analysis of the E-cadherin (CDH1) gene in a cohort of gastric cancers seen in the Western Cape Jaca, Anelisa Naidoo, Richard Includes abstract. Includes bibliographical references. Gastric cancer is commonly seen in the Western Cape. There are numerous factors that contribute to the development of this cancer and these include both environmental and genetic factors. Amongst the genetic factors, the E-cadherin (CDH1) gene is said to play a major role in the development of gastric cancer. Both germline and somatic mutations have been identified in the CDH1 gene. The germline mutations span the entire exon of this gene and are seen in approximately 29% to 56% of familial gastric cancers. On the other hand, CDH1 somatic mutations are seen in approximately 31% of sporadic cancers. These mutations have been identified in exons 7 to 10, with exons 8 and 9 being the commonly mutated regions. The primary objective of this study was to determine the prevalence of CDH1 genetic mutations in gastric cancer in the Western Cape and to correlate these findings with the demographic/clinicopathologic data. 2014-07-28T14:57:27Z 2014-07-28T14:57:27Z 2013 Master Thesis Masters MSc http://hdl.handle.net/11427/3165 eng application/pdf Department of Clinical Laboratory Sciences Faculty of Health Sciences University of Cape Town |
| spellingShingle | Jaca, Anelisa Sequence analysis of the E-cadherin (CDH1) gene in a cohort of gastric cancers seen in the Western Cape |
| thesis_degree_str | Master's |
| title | Sequence analysis of the E-cadherin (CDH1) gene in a cohort of gastric cancers seen in the Western Cape |
| title_full | Sequence analysis of the E-cadherin (CDH1) gene in a cohort of gastric cancers seen in the Western Cape |
| title_fullStr | Sequence analysis of the E-cadherin (CDH1) gene in a cohort of gastric cancers seen in the Western Cape |
| title_full_unstemmed | Sequence analysis of the E-cadherin (CDH1) gene in a cohort of gastric cancers seen in the Western Cape |
| title_short | Sequence analysis of the E-cadherin (CDH1) gene in a cohort of gastric cancers seen in the Western Cape |
| title_sort | sequence analysis of the e cadherin cdh1 gene in a cohort of gastric cancers seen in the western cape |
| url | http://hdl.handle.net/11427/3165 |
| work_keys_str_mv | AT jacaanelisa sequenceanalysisoftheecadherincdh1geneinacohortofgastriccancersseeninthewesterncape |