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The influence of maternal Nippostrongylus brasiliensis infection on immunity in offspring
Includes abstract.
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| Main Author: | |
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
| Published: |
Department of Clinical Laboratory Sciences
2014
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| _version_ | 1867613249688567808 |
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| access_status_str | Open Access |
| author | Mrdjen, Dunja |
| author2 | Horsnell, William |
| author_browse | Horsnell, William Mrdjen, Dunja |
| author_facet | Horsnell, William Mrdjen, Dunja |
| author_sort | Mrdjen, Dunja |
| collection | Thesis |
| description | Includes abstract. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/3175 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:33:08.525Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2014 |
| publishDateRange | 2014 |
| publishDateSort | 2014 |
| publisher | Department of Clinical Laboratory Sciences |
| publisherStr | Department of Clinical Laboratory Sciences |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/3175 The influence of maternal Nippostrongylus brasiliensis infection on immunity in offspring Mrdjen, Dunja Horsnell, William Clinical Laboratory Sciences Includes abstract. Includes bibliographical references. This study investigates imprinting of the murine fetal immune system by maternal infection with the helminth Nippostrongylus brasiliensis (Nb) prior to pregnancy and its effect on control of the Salmonella enterica serovar typhimurium (STm) in offspring. We show that maternal Nb infection in BALB/c mice results in the transfer of Nb antigen (NES)-specific IgG1 in utero and through breastmilk, changes in lymphocyte populations and early germinal center formation in naive offspring. Maternal Nb infection does not interfere with control of STm in offspring in BALB/c mice, but may interfere with control of STm in C57BL/6 mice. 2014-07-28T14:57:43Z 2014-07-28T14:57:43Z 2013 Master Thesis Masters MMed http://hdl.handle.net/11427/3175 eng application/pdf Department of Clinical Laboratory Sciences Faculty of Health Sciences University of Cape Town |
| spellingShingle | Clinical Laboratory Sciences Mrdjen, Dunja The influence of maternal Nippostrongylus brasiliensis infection on immunity in offspring |
| thesis_degree_str | Master's |
| title | The influence of maternal Nippostrongylus brasiliensis infection on immunity in offspring |
| title_full | The influence of maternal Nippostrongylus brasiliensis infection on immunity in offspring |
| title_fullStr | The influence of maternal Nippostrongylus brasiliensis infection on immunity in offspring |
| title_full_unstemmed | The influence of maternal Nippostrongylus brasiliensis infection on immunity in offspring |
| title_short | The influence of maternal Nippostrongylus brasiliensis infection on immunity in offspring |
| title_sort | influence of maternal nippostrongylus brasiliensis infection on immunity in offspring |
| topic | Clinical Laboratory Sciences |
| url | http://hdl.handle.net/11427/3175 |
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